马促肾上腺皮质激素的季节性升高发生在整个邻近的美国,并受纬度和年龄的影响。

IF 1.8 2区 农林科学 Q2 VETERINARY SCIENCES
Toby L Pinn-Woodcock, Sebastián G Llanos-Soto, Renata Ivanek, Erin Goodrich, Elisha Frye, Amy Wells, Kathleen Mullen, Elizabeth Arbittier, Lauren Hughes, Emily Berryhill, Peggy Brosnahan, Lauren Buslinger, Lauren Schnabel, Sally DeNotta, Martha Mallicote, Simon Peek, Ned J Place
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引用次数: 0

摘要

目的:研究美国纬度在29.7°N到45.0°N之间是否会影响马血浆ACTH浓度的季节变化。方法:在2019年6月至2020年5月期间进行队列研究,采用化学发光免疫分析法每月测量血浆ACTH。这项研究涉及来自美国9个地区的201匹明显健康的马,它们被分为北纬、中纬度和南纬三组。数据分析有三个主要目的:(1)识别异常的ACTH浓度和马;(2)估计促肾上腺皮质激素参考上限,以确定健康马的预期促肾上腺皮质激素浓度;(3)利用线性混合效应回归模型识别影响ACTH浓度的因素。结果:经过异常值分析,来自3个纬度队列的154匹马:北部(n = 29),中部(84)和南部(41)。ACTH浓度在8月下旬、9月和10月初最高。在15岁以上的马中,ACTH全年高于年轻马,在ACTH的季节性升高期间增加幅度更大。结论:在整个美国邻近地区,马的ACTH季节性升高,与中心队列相比,南部马的ACTH较低。需要进一步的研究来确定纬度对靠近赤道的马的影响,以及与季节升高开始相一致的光周期变化在马ACTH中的作用。临床相关性:在解释美国各地马的ACTH基线浓度时,应考虑季节和年龄。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seasonal elevation in equine adrenocorticotropic hormone occurs throughout the contiguous United States and is influenced by latitude and age.

Objective: To determine whether seasonal variation in equine plasma ACTH concentrations is affected by latitude between 29.7°N and 45.0°N in the US.

Methods: A cohort study was performed between June 2019 and May 2020 in which plasma ACTH was measured monthly by chemiluminescence immunoassay. The study involved 201 apparently healthy horses from 9 locations within the US classified into northern, central, and southern latitude cohorts. Data analysis was performed with 3 major objectives: (1) identify outlier ACTH concentrations and horses; (2) estimate ACTH upper reference limits to define expected ACTH concentrations in healthy horses; and (3) identify factors influencing ACTH concentrations using linear mixed-effects regression models.

Results: Following outlier analysis, 154 horses remained from 3 latitude cohorts: northern (n = 29), central (84), and southern (41). Concentrations of ACTH were highest during late August and September and early October for all latitude cohorts. In horses over 15 years of age, ACTH was higher than in younger horses year-round, with a greater magnitude of increase during the seasonal elevation in ACTH.

Conclusions: A seasonal elevation in ACTH occurred in horses throughout the contiguous US, with lower ACTH in horses in the southern compared to central cohort. Further investigation is required to determine the influence of latitude on horses that reside closer to the equator and the role of the changing photoperiod coinciding with the start of seasonal elevation in equine ACTH.

Clinical relevance: Season and age should be considered when interpreting baseline ACTH concentrations in horses throughout the contiguous US.

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来源期刊
CiteScore
1.60
自引率
15.80%
发文量
539
审稿时长
6-16 weeks
期刊介绍: Published twice monthly, this peer-reviewed, general scientific journal provides reports of clinical research, feature articles and regular columns of interest to veterinarians in private and public practice. The News and Classified Ad sections are posted online 10 days to two weeks before they are delivered in print.
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