RUNX1::RUNX1T1阳性急性髓系白血病继发于分离性乳腺髓系肉瘤1例报告及文献复习

IF 1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Annals of clinical and laboratory science Pub Date : 2025-05-01

Gui-Rui Sang, Chun-Li Xu, Dong-Ping Huang, Yu Chen

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引用次数: 0

摘要

目的：乳腺分离性髓系肉瘤（IMS）极为罕见，目前治疗乳腺分离性髓系肉瘤继发的急性髓系白血病（AML）的方法更为罕见。本病的临床特点及治疗策略值得探讨。病例报告：我们描述了一例发生在乳房的37岁女性IMS，她在不到两年的时间里发展为RUNX1::RUNX1T1阳性AML。随后给予维内托克乐联合低甲基化药物治疗，疗效良好。讨论：在以venetoclax为基础的治疗后，她至今仍处于完全缓解（CR）状态。结论：乳腺IMS是罕见的，但高度进展到AML。影像学和组织病理学是诊断的关键工具，以venetoclax为基础的治疗方案可能是一种很有前途的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

RUNX1::RUNX1T1 Positive Acute Myeloid Leukemia Secondary to Isolated Breast Myeloid Sarcoma: A Case Report and Literature Review.

Objective: Isolated Myeloid sarcoma (IMS) of breast is extremely rare and current treatment approaches for Acute Myeloid Leukemia (AML) secondary to breast IMS are even rarer. It is worthwhile to explore the clinical features of this disease and the promising treatment strategy.

Case report: We described one case of IMS that occurred in the breast in a 37-year-old female, who progressed to RUNX1::RUNX1T1 positive AML in less than two years. Then, she was treated with Venetoclax plus hypomethylating agents, which showed favorable response.

Discussion: She has remained in complete remission (CR) to date after the Venetoclax-based treatment.

Conclusions: Breast IMS is rare but highly progressive to AML. Imaging and histopathology are key tools in diagnosing it and Venetoclax-based regimens may be a promising treatment strategy.

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来源期刊

Annals of clinical and laboratory science 医学-医学实验技术

CiteScore

1.60

自引率

0.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： The Annals of Clinical & Laboratory Science welcomes manuscripts that report research in clinical science, including pathology, clinical chemistry, biotechnology, molecular biology, cytogenetics, microbiology, immunology, hematology, transfusion medicine, organ and tissue transplantation, therapeutics, toxicology, and clinical informatics.