中耳炎积液中存在微塑料

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology Pub Date : 2025-07-30 DOI:10.1016/j.ijporl.2025.112501

Kerem Kökoğlu , Hamdi Mıhçıokur , Ibrahim Uyanık , Dilşad Öztürk , Halit Yıldız , Onat Berkay Taş , Rabia Aybüke Kaplan

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引用次数: 0

摘要

目的探讨中耳炎患儿中耳积液中微塑料的存在及特征。方法收集24例患者中耳积液，其中男13例，女11例；平均年龄5.4岁)，双侧OME（持续时间≥3个月）或单侧OME（持续时间≥9个月）行鼓膜切开术。抽吸积液，用过滤蒸馏水洗涤，用10% KOH处理，孵育。然后用0.7 μm玻璃纤维过滤器过滤样品，用丙酮洗涤，并用孟加拉玫瑰染色。利用傅里叶变换红外光谱和拉曼显微镜对微塑料的存在和表征进行了评估。结果40份MEE样品中检出微塑料11份（27.5%）。两名患者表现出双侧微塑性存在。鉴定的微塑料包括丙烯腈丁二烯苯乙烯、聚氨酯乙二醇、聚甲基硅氧烷、聚丙烯、聚二乙基氯磷酸酯和聚酰胺。结论本研究为OME患者的MEEs中存在微塑料提供了初步证据，值得进一步研究潜在的影响。临床试验编号：bernct06316635。

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Microplastic presence in the fluid of otitis media with effusion

Objective

To investigate the presence and characterize microplastics in middle ear effusions from children with otitis media with effusion.

Methods

Middle ear effusions were collected from 24 patients (13 males, 11 females; mean age 5.4 years) with bilateral OME (≥3 months duration) or unilateral OME (≥9 months duration) undergoing myringotomy. Effusions were aspirated, washed with filtered distilled water, treated with 10 % KOH, and incubated. Samples were then filtered through a 0.7 μm glass fiber filter, washed with acetone, and stained with rose Bengal. Microplastic presence and characterization were assessed using Fourier transform infrared spectroscopy and Raman microscopy.

Results

Microplastics were detected in 11 of 40 MEE samples (27.5 %). Two patients exhibited bilateral microplastic presence. Identified microplastics included acrylonitrile butadiene styrene, polyurethane glycol, polymethyl siloxane, polypropylene, polyethylene diethyl chlorophosphite, and polyamide.

Conclusion

This study provides preliminary evidence for the presence of microplastics in MEEs of patients with OME, warranting further investigation into potential implications.

Clinical trials number

NCT06316635.

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来源期刊

International journal of pediatric otorhinolaryngology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.70%

发文量

276

审稿时长

62 days

期刊介绍： The purpose of the International Journal of Pediatric Otorhinolaryngology is to concentrate and disseminate information concerning prevention, cure and care of otorhinolaryngological disorders in infants and children due to developmental, degenerative, infectious, neoplastic, traumatic, social, psychiatric and economic causes. The Journal provides a medium for clinical and basic contributions in all of the areas of pediatric otorhinolaryngology. This includes medical and surgical otology, bronchoesophagology, laryngology, rhinology, diseases of the head and neck, and disorders of communication, including voice, speech and language disorders.