有机光氧化还原催化1,2 -氢原子转移通过自由基-极性交叉环化级联合成环丙烷

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-09-26 DOI:10.1002/adsc.70045

Zeyu Tian , Dongqin He , Jun Liang , Qing Liu , Meiling Ye , Li Hai , Guanghui Lv , Yong Wu

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引用次数: 0

摘要

环丙烷是一种普遍存在于药物和天然产物中的合成材料，是药物化学领域探索的一个重要方面。然而，目前环丙烷的合成方法面临着许多环境和实际挑战，强调了构建更可持续的方案的必要性。本文公开了一种有机光氧化还原催化自由基-极性交叉环化级联方案，该方案通过1,2 -氢原子转移合成环丙烷，其特点是条件温和，底物范围广。此外，还进行了药物分子相容性、放大实验和合成转化实验，验证了该方案的潜在应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Organic Photoredox‐Catalyzed 1,2‐Hydrogen Atom Transfer Enables the Synthesis of Cyclopropanes via Radical‐Polar Crossover Cyclization Cascade

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Organic Photoredox‐Catalyzed 1,2‐Hydrogen Atom Transfer Enables the Synthesis of Cyclopropanes via Radical‐Polar Crossover Cyclization Cascade

Cyclopropane is a prevalent synthetic building block present in pharmaceuticals and natural products, becoming a significant dimension for exploration in the fields of medicinal chemistry. However, the current synthesis methods for cyclopropane face numerous environmental and practical challenges, emphasizing the necessity of constructing more sustainable protocols. Herein, an organic photoredox‐catalyzed radical‐polar crossover cyclization cascade protocol for the synthesis of cyclopropanes enabled by 1,2‐hydrogen atom transfer is disclosed, which is distinguished by mild conditions, a broad range of substrates. Besides, drug molecules compatibility, scale‐up experiment, and synthetic transformations are performed to prove the potential application value of this protocol.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.