羰基二咪唑催化溴化苄基的亲核三氟甲氧基化

IF 2.7 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-09-23 DOI:10.1002/ejoc.202500529

Ziyue Zhu , Yijie Xu , Samantha Kyriazakos , G. K. Surya Prakash

引用次数: 0

摘要

提出了一种操作简单的亲核三氟甲氧基化方案，通过廉价、市售和稳定的试剂，羰基二咪唑和AgF。机理研究表明，该方法不通过传统的三氟甲氧基阴离子途径，产生有毒的二氟光气作为中间体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Nucleophilic Trifluoromethoxylation of Benzyl Bromides via Carbonyl Diimidazole

查看原文本刊更多论文

Nucleophilic Trifluoromethoxylation of Benzyl Bromides via Carbonyl Diimidazole

An operationally simple nucleophilic trifluoromethoxylation protocol via an inexpensive, commercially available and bench stable reagent, carbonyl diimidazole and AgF is presented. Mechanistic studies are performed to reveal that this method does not proceed through the conventional trifluoromethoxide anion pathway that generates toxic difluorophosgene as an intermediate.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.