微塑料和妇科肿瘤:一个新兴的环境健康问题。

IF 2.8 4区 医学 Q2 REPRODUCTIVE BIOLOGY
Reproductive toxicology Pub Date : 2025-10-01 Epub Date: 2025-07-29 DOI:10.1016/j.reprotox.2025.109018
Yuling Hu, Zhihui Song, Jingwen Li, Feiyi Yang, Ling Li
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引用次数: 0

摘要

微塑料(MPs)对环境的普遍污染已成为对人类健康的重大威胁,越来越多的证据表明,接触微塑料与妇科肿瘤有关。这篇全面的综述综合了目前的科学证据,通过检查化学添加剂的既定风险,探索颗粒本身的致癌机制,并强调了最近在人类妇科组织中直接检测到的MPs。这种关联的证据是多方面的:塑料添加剂,如邻苯二甲酸盐和双酚A (BPA)在流行病学上与癌症风险增加有关,而MP颗粒本身被证明会诱发致癌反应,包括氧化应激、慢性炎症和表观遗传变化。重要的是,最近的研究现在证实了MPs在人类妇科肿瘤组织中的物理存在,其浓度通常高于邻近正常组织,从而加强了这些发现的临床相关性。化学、机制和临床证据的融合建立了MP暴露作为妇科恶性肿瘤新出现的危险因素的令人信服的案例。研究结果强调,迫切需要进一步研究、标准化检测方法和公共卫生战略,以减轻这一环境威胁。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microplastics and gynecological tumors: An emerging environmental health concern.

The pervasive environmental contamination by microplastics (MPs) has emerged as a significant threat to human health, with mounting evidence linking exposure to gynecological tumors. This comprehensive review synthesizes current scientific evidence by examining the established risks of chemical additives, exploring the carcinogenic mechanisms of the particles themselves, and highlighting the recent direct detection of MPs in human gynecological tissues. Evidence for this association is multi-faceted: plastic additives such as phthalates and bisphenol A (BPA) are epidemiologically linked to increased cancer risk, while the MP particles themselves are shown to induce pro-carcinogenic responses including oxidative stress, chronic inflammation, and epigenetic changes. Critically, recent studies now confirm the physical presence of MPs within human gynecological tumor tissues, often at higher concentrations than in adjacent normal tissue, strengthening the clinical relevance of these findings. The convergence of chemical, mechanistic, and clinical evidence establishes a compelling case for MP exposure as an emerging risk factor for gynecological malignancies. The findings underscore an urgent need for further research, standardized detection methodologies, and public health strategies to mitigate this environmental threat.

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来源期刊
Reproductive toxicology
Reproductive toxicology 生物-毒理学
CiteScore
6.50
自引率
3.00%
发文量
131
审稿时长
45 days
期刊介绍: Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine. All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.
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