伊朗2021年SARS-CoV-2免疫球蛋白G血清流行病学分析

IF 2.6 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
PLoS ONE Pub Date : 2025-07-31 eCollection Date: 2025-01-01 DOI:10.1371/journal.pone.0313795
Mohammadreza Azangou-Khyavy, Erfan Ghasemi, Narges Ebrahimi, Mohammad-Mahdi Rashidi, Mohsen Abbasi-Kangevari, Naser Ahmadi, Javad Khanali, Ameneh Kazemi, Arezou Dilmaghani-Marand, Yosef Farzi, Moein Yoosefi, Elham Abdolhamidi, Mana Moghimi, Maryam Nasserinejad, Nima Fattahi, Sina Azadnajafabad, Arefe Alipour-Daroei, Kamyar Rezaee, Shirin Djalalinia, Negar Rezaei, Hamidreza Jamshidi, Farshad Farzadfar
{"title":"伊朗2021年SARS-CoV-2免疫球蛋白G血清流行病学分析","authors":"Mohammadreza Azangou-Khyavy, Erfan Ghasemi, Narges Ebrahimi, Mohammad-Mahdi Rashidi, Mohsen Abbasi-Kangevari, Naser Ahmadi, Javad Khanali, Ameneh Kazemi, Arezou Dilmaghani-Marand, Yosef Farzi, Moein Yoosefi, Elham Abdolhamidi, Mana Moghimi, Maryam Nasserinejad, Nima Fattahi, Sina Azadnajafabad, Arefe Alipour-Daroei, Kamyar Rezaee, Shirin Djalalinia, Negar Rezaei, Hamidreza Jamshidi, Farshad Farzadfar","doi":"10.1371/journal.pone.0313795","DOIUrl":null,"url":null,"abstract":"<p><p>Multiple factors challenge PCR test results for COVID-19 infection, and only symptomatic cases have been tested. Thus, a population-based seroprevalence study was necessary to determine the extent of missed cases. The objective of this study was to achieve a realistic infection rate in Iran and probe into some explanations behind being infected or not. In this population-based cross-sectional study, 16,610 adults aged more than 25 with valid serology sample results from 31 provinces from February to April 2021 were included. According to the ELISA kits based on the N antigen of SARS-CoV-2, the seroprevalence of IgG against SARS-CoV-2 in Iran was 20.63% (19.71-21.56) and 16.25% (15.11-17.41) based on two different corrections. The age-standardized seroprevalence was relatively high among Kurdistan [30.29% (26.04-34.55) and 28.31% (23-33.61)] and West Azarbayejan [29.33% (24.85-33.8) and 27.11% (21.52-32.68)]. Smoking, higher education, being underweight, male, and single were protective factors, and higher daily interactions was a risk for seropositivity. It is evident that reported infection rates have been misleading. Furthermore, several intervenable factors can predict the risk of infection.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 7","pages":"e0313795"},"PeriodicalIF":2.6000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312912/pdf/","citationCount":"0","resultStr":"{\"title\":\"National and sub-national sero-epidemiology of immunoglobulin G against SARS-CoV-2 in Iran in 2021.\",\"authors\":\"Mohammadreza Azangou-Khyavy, Erfan Ghasemi, Narges Ebrahimi, Mohammad-Mahdi Rashidi, Mohsen Abbasi-Kangevari, Naser Ahmadi, Javad Khanali, Ameneh Kazemi, Arezou Dilmaghani-Marand, Yosef Farzi, Moein Yoosefi, Elham Abdolhamidi, Mana Moghimi, Maryam Nasserinejad, Nima Fattahi, Sina Azadnajafabad, Arefe Alipour-Daroei, Kamyar Rezaee, Shirin Djalalinia, Negar Rezaei, Hamidreza Jamshidi, Farshad Farzadfar\",\"doi\":\"10.1371/journal.pone.0313795\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Multiple factors challenge PCR test results for COVID-19 infection, and only symptomatic cases have been tested. Thus, a population-based seroprevalence study was necessary to determine the extent of missed cases. The objective of this study was to achieve a realistic infection rate in Iran and probe into some explanations behind being infected or not. In this population-based cross-sectional study, 16,610 adults aged more than 25 with valid serology sample results from 31 provinces from February to April 2021 were included. According to the ELISA kits based on the N antigen of SARS-CoV-2, the seroprevalence of IgG against SARS-CoV-2 in Iran was 20.63% (19.71-21.56) and 16.25% (15.11-17.41) based on two different corrections. The age-standardized seroprevalence was relatively high among Kurdistan [30.29% (26.04-34.55) and 28.31% (23-33.61)] and West Azarbayejan [29.33% (24.85-33.8) and 27.11% (21.52-32.68)]. Smoking, higher education, being underweight, male, and single were protective factors, and higher daily interactions was a risk for seropositivity. It is evident that reported infection rates have been misleading. Furthermore, several intervenable factors can predict the risk of infection.</p>\",\"PeriodicalId\":20189,\"journal\":{\"name\":\"PLoS ONE\",\"volume\":\"20 7\",\"pages\":\"e0313795\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12312912/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"PLoS ONE\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1371/journal.pone.0313795\",\"RegionNum\":3,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"PLoS ONE","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1371/journal.pone.0313795","RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

多重因素对COVID-19感染的PCR检测结果提出质疑,目前只对有症状的病例进行了检测。因此,有必要进行基于人群的血清患病率研究,以确定漏诊病例的程度。本研究的目的是获得伊朗真实的感染率,并探讨感染与否背后的一些解释。在这项基于人群的横断面研究中,2021年2月至4月,来自31个省份的16610名年龄在25岁以上的成年人获得了有效的血清学样本结果。根据基于SARS-CoV-2 N抗原的ELISA试剂盒,经两次校正后,伊朗地区IgG对SARS-CoV-2的血清阳性率分别为20.63%(19.71 ~ 21.56)和16.25%(15.11 ~ 17.41)。库尔德斯坦地区(30.29%(26.04-34.55)和28.31%(23-33.61))和西阿扎尔巴耶jan地区(29.33%(24.85-33.8)和27.11%(21.52-32.68))的年龄标准化血清阳性率较高。吸烟、高等教育、体重过轻、男性和单身是保护因素,较高的日常互动是血清阳性的风险。报告的感染率显然具有误导性。此外,一些可干预的因素可以预测感染的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

National and sub-national sero-epidemiology of immunoglobulin G against SARS-CoV-2 in Iran in 2021.

National and sub-national sero-epidemiology of immunoglobulin G against SARS-CoV-2 in Iran in 2021.

National and sub-national sero-epidemiology of immunoglobulin G against SARS-CoV-2 in Iran in 2021.

National and sub-national sero-epidemiology of immunoglobulin G against SARS-CoV-2 in Iran in 2021.

Multiple factors challenge PCR test results for COVID-19 infection, and only symptomatic cases have been tested. Thus, a population-based seroprevalence study was necessary to determine the extent of missed cases. The objective of this study was to achieve a realistic infection rate in Iran and probe into some explanations behind being infected or not. In this population-based cross-sectional study, 16,610 adults aged more than 25 with valid serology sample results from 31 provinces from February to April 2021 were included. According to the ELISA kits based on the N antigen of SARS-CoV-2, the seroprevalence of IgG against SARS-CoV-2 in Iran was 20.63% (19.71-21.56) and 16.25% (15.11-17.41) based on two different corrections. The age-standardized seroprevalence was relatively high among Kurdistan [30.29% (26.04-34.55) and 28.31% (23-33.61)] and West Azarbayejan [29.33% (24.85-33.8) and 27.11% (21.52-32.68)]. Smoking, higher education, being underweight, male, and single were protective factors, and higher daily interactions was a risk for seropositivity. It is evident that reported infection rates have been misleading. Furthermore, several intervenable factors can predict the risk of infection.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
PLoS ONE
PLoS ONE 生物-生物学
CiteScore
6.20
自引率
5.40%
发文量
14242
审稿时长
3.7 months
期刊介绍: PLOS ONE is an international, peer-reviewed, open-access, online publication. PLOS ONE welcomes reports on primary research from any scientific discipline. It provides: * Open-access—freely accessible online, authors retain copyright * Fast publication times * Peer review by expert, practicing researchers * Post-publication tools to indicate quality and impact * Community-based dialogue on articles * Worldwide media coverage
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信