351例声带白斑患者的回顾性分析:吸烟、病变大小和组织病理学分级对治疗结果的影响。

IF 0.8 4区 医学 Q3 OTORHINOLARYNGOLOGY
Xueqian Yang, Liang Peng, Ruihua Fang, Lin Chen, Zhangwei Hu, Dan Wang, Renqiang Ma, Jie Deng, Xiaolin Zhu, Zhangfeng Wang, Weiping Wen, Wenbin Lei, Wei Sun
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引用次数: 0

摘要

目的:探讨声带白斑的治疗方法及影响预后的因素。方法:观察保守和手术治疗方法,分析影响声带白斑预后的因素。结果:在保守治疗组,病变大小(p = 0.035)和吸烟(p < 0.001)是影响治疗结果的独立因素。在手术治疗组中,病变大小(p = 0.018)被确定为影响复发的独立因素。对于增生(p = 0.223)、轻度发育不良(p = 0.634)和中度发育不良(p = 0.758)患者,保守治疗与手术治疗的疗效差异无统计学意义。结论:吸烟和病变大小是影响保守治疗结果的关键因素,而病变大小是影响手术治疗患者复发的重要因素。更重要的是,对于中度发育不良和轻度声带白斑的患者应优先进行保守治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Retrospective analysis of 351 patients with vocal fold leukoplakia: impact of smoking, lesion size and histopathological grade on treatment outcomes.

Objective: To explore the treatment options and prognostic factors of vocal fold leukoplakia.

Methods: The study examined conservative and surgical treatment approaches, and analysed prognostic factors influencing vocal fold leukoplakia outcomes.

Results: In the conservative treatment group, lesion size (p = 0.035) and smoking (p < 0.001) were identified as independent factors influencing treatment outcomes. In the surgical treatment group, lesion size (p = 0.018) was identified as an independent factor affecting recurrence. There was no statistically significant difference in the effectiveness of conservative versus surgical treatment for patients with hyperplasia (p = 0.223), mild dysplasia (p = 0.634) and moderate dysplasia (p = 0.758).

Conclusion: Smoking and lesion size are key factors influencing the outcome of conservative treatment, while lesion size is a significant factor affecting recurrence in surgically treated patients. More importantly, conservative treatment should be prioritised for patients with moderate dysplasia and milder vocal fold leukoplakia.

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来源期刊
Journal of Laryngology and Otology
Journal of Laryngology and Otology 医学-耳鼻喉科学
CiteScore
3.20
自引率
11.80%
发文量
593
审稿时长
3-6 weeks
期刊介绍: The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.
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