喉发育不良：前连合受累与浸润性癌进展的关系。

IF 0.8 4区医学 Q3 OTORHINOLARYNGOLOGY

Journal of Laryngology and Otology Pub Date : 2025-08-01 DOI:10.1017/S0022215125102521

Ebru Karakaya Gojayev, Zahide Çiler Büyükatalay Yaldız, Gürsel Dursun, Kürşat Gökcan

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引用次数: 0

摘要

目的：喉发育不良是喉内的癌前病变。本研究旨在通过分析长期随访数据来确定影响癌症进展的因素。方法：回顾性分析2005年至2017年诊断的221例患者的资料。比较患者人口统计学、治疗策略和随访结果。结果：26例（11.7%）患者进展为癌症。在癌症进展和从前连合获得的初始活检之间发现了显著的关联(进展病例为34.6%，非进展病例为6.2%；P < 0.001)。原位癌的进展率（21.7%）高于轻度发育不良（3.4%）（p = 0.007）。癌症进展组也有更高的其他癌症发病率(15.4%对2.1%；P = 0.008)，包括肺癌(11.5% vs. 0%；P = 0.001)。结论：本研究确定喉发育不良发展为癌的进展率为11.7%。累及前连合的病变进展风险增加约8.1倍。

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Laryngeal dysplasia: relationship between anterior commissure involvement and progression to invasive cancer.

Objectives: Laryngeal dysplasia is a pre-cancerous lesion within the larynx. This study aims to identify factors influencing progression to cancer by analysing long-term follow-up data.

Methods: Data from 221 patients diagnosed between 2005 and 2017 were reviewed retrospectively. Patient demographics, treatment strategies and follow-up results were compared.

Results: Progression to cancer occurred in 26 patients (11.7 per cent). A significant association was found between cancer progression and initial biopsies obtained from the anterior commissure (34.6 per cent in progressing cases vs. 6.2 per cent in non-progressing; p < 0.001). Carcinoma in situ cases showed a higher progression rate (21.7%) compared to mild dysplasia (3.4 per cent) (p = 0.007). The group with cancer progression also had higher rates of other cancers (15.4 per cent vs. 2.1 per cent; p = 0.008), including lung cancer (11.5 per cent vs. 0 per cent; p = 0.001).

Conclusion: The study determined an 11.7 per cent progression rate of laryngeal dysplasia to cancer. Lesions involving the anterior commissure carried an approximately 8.1-fold increased risk of progression.

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来源期刊

Journal of Laryngology and Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

11.80%

发文量

593

审稿时长

3-6 weeks

期刊介绍： The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.