{"title":"溶组织内阿米巴凝集素和p53蛋白在结直肠癌中的存在及其相互作用。","authors":"Leila Haghighi, Abdolhossein Dalimi, Majid Pirestani, Fatemeh Ghaffarifar","doi":"10.18502/ijpa.v20i2.19031","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>We aimed to analyze the presence of <i>Entamoeba histolytica</i> lectin light chain antigen and <i>p53</i> protein in colorectal cancer biopsies to uncover potential antigenic interactions between them.</p><p><strong>Methods: </strong>Overall, 150 colorectal cancer biopsy samples were subjected to examination for the specific <i>E. histolytica</i> antigen and <i>p53</i> protein through the application of the immunohistochemical technique. To augment diagnostic precision, the western blotting method was employed and its results were compared with those obtained from immunohistochemistry (IHC).</p><p><strong>Results: </strong>Among the 150 colorectal cancer biopsy samples examined, 100 cases tested positive for the <i>p53</i> protein, while 19 cases exhibited positivity for the <i>E. histolytica</i> light chain lectin antigen. Notably, only 14 cases demonstrated a positive presence for both the <i>p53</i> protein and the <i>E. histolytica</i> protozoan.</p><p><strong>Conclusion: </strong><i>Entamoeba histolytica</i>, a leading cause of parasitic infections, raises questions about its potential link to colorectal cancer, specifically in connection with the <i>p53</i> protein. The findings presented in this investigation signal the need for further research to comprehensively understand the implications of <i>E. histolytica</i> in colorectal cancer diagnosis and treatment strategies.</p>","PeriodicalId":14669,"journal":{"name":"Iranian Journal of Parasitology","volume":"20 2","pages":"245-252"},"PeriodicalIF":0.9000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307784/pdf/","citationCount":"0","resultStr":"{\"title\":\"Presence and Interactions of <i>Entamoeba histolytica</i> Lectin and <i>p53</i> Protein in Colorectal Cancer.\",\"authors\":\"Leila Haghighi, Abdolhossein Dalimi, Majid Pirestani, Fatemeh Ghaffarifar\",\"doi\":\"10.18502/ijpa.v20i2.19031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>We aimed to analyze the presence of <i>Entamoeba histolytica</i> lectin light chain antigen and <i>p53</i> protein in colorectal cancer biopsies to uncover potential antigenic interactions between them.</p><p><strong>Methods: </strong>Overall, 150 colorectal cancer biopsy samples were subjected to examination for the specific <i>E. histolytica</i> antigen and <i>p53</i> protein through the application of the immunohistochemical technique. To augment diagnostic precision, the western blotting method was employed and its results were compared with those obtained from immunohistochemistry (IHC).</p><p><strong>Results: </strong>Among the 150 colorectal cancer biopsy samples examined, 100 cases tested positive for the <i>p53</i> protein, while 19 cases exhibited positivity for the <i>E. histolytica</i> light chain lectin antigen. Notably, only 14 cases demonstrated a positive presence for both the <i>p53</i> protein and the <i>E. histolytica</i> protozoan.</p><p><strong>Conclusion: </strong><i>Entamoeba histolytica</i>, a leading cause of parasitic infections, raises questions about its potential link to colorectal cancer, specifically in connection with the <i>p53</i> protein. The findings presented in this investigation signal the need for further research to comprehensively understand the implications of <i>E. histolytica</i> in colorectal cancer diagnosis and treatment strategies.</p>\",\"PeriodicalId\":14669,\"journal\":{\"name\":\"Iranian Journal of Parasitology\",\"volume\":\"20 2\",\"pages\":\"245-252\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307784/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Parasitology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.18502/ijpa.v20i2.19031\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PARASITOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Parasitology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18502/ijpa.v20i2.19031","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PARASITOLOGY","Score":null,"Total":0}
Presence and Interactions of Entamoeba histolytica Lectin and p53 Protein in Colorectal Cancer.
Background: We aimed to analyze the presence of Entamoeba histolytica lectin light chain antigen and p53 protein in colorectal cancer biopsies to uncover potential antigenic interactions between them.
Methods: Overall, 150 colorectal cancer biopsy samples were subjected to examination for the specific E. histolytica antigen and p53 protein through the application of the immunohistochemical technique. To augment diagnostic precision, the western blotting method was employed and its results were compared with those obtained from immunohistochemistry (IHC).
Results: Among the 150 colorectal cancer biopsy samples examined, 100 cases tested positive for the p53 protein, while 19 cases exhibited positivity for the E. histolytica light chain lectin antigen. Notably, only 14 cases demonstrated a positive presence for both the p53 protein and the E. histolytica protozoan.
Conclusion: Entamoeba histolytica, a leading cause of parasitic infections, raises questions about its potential link to colorectal cancer, specifically in connection with the p53 protein. The findings presented in this investigation signal the need for further research to comprehensively understand the implications of E. histolytica in colorectal cancer diagnosis and treatment strategies.
期刊介绍：
Iranian Journal of Parasitology (IJP) is the official publication of Iranian Society of Parasitology (ISP) launched in 2006. The society was inaugurated in 1994 and pursues the improvement of the knowledge on the parasites and parasitic diseases, exchange of scientific knowledge with foreign societies, publicity activities, and consultation on the parasitic diseases, and intimate relationship among society members.
The main aims of the Journal are: contribution to the field of Parasitology, including all aspects of parasites and parasitic diseases (medical and veterinary) and related fields such as Entomology which may be submitted by scientists from Iran and all over the world.
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