国家阿尔茨海默病协调中心心房颤动的脑神经病理学和认知功能。

IF 3.1 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-10-01 Epub Date: 2025-08-01 DOI:10.1177/13872877251364508

Kathryn A Wood, Xinyue Chen, Yi-An Ko, Whitney Wharton, Marla Gearing

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引用次数: 0

摘要

许多研究表明心房颤动（AF）与痴呆或阿尔茨海默病（AD）之间的关系。使用国家阿尔茨海默病协调中心（NACC）脑尸检队列，采用逻辑回归和有序逻辑回归探讨AF （N = 3558）的神经病理学。AF与CERAD神经斑块密度差异显著相关（估计差异0.76,95% CI =[0.63, 0.92]）。AF患者的Braak和NIA/Reagan评分较高，表明AF患者的神经病理学更差；然而，经过多次测试调整后，这并不显著。这些发现表明，房颤与较高痴呆风险之间的关联不太可能是由原发性痴呆相关机制介导的。

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National Alzheimer's Coordinating Center cerebral neuropathology and cognitive function in atrial fibrillation.

Many studies have shown a relationship between atrial fibrillation (AF) and dementia or Alzheimer's disease (AD). The National Alzheimer's Coordinating Center (NACC) brain autopsy cohort was used to explore neuropathology in AF (N = 3558) using logistic and ordinal logistic regression. AF was significantly associated with differences in CERAD neuritic plaque density (estimated difference 0.76, 95% CI = [0.63, 0.92]). Subjects with AF had higher Braak and NIA/Reagan Scores, indicating worse neuropathology in AF; this was not significant however, after multiple testing adjustment. These findings suggest that the association between AF and higher dementia risk is unlikely mediated by primary dementia-related mechanisms.

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.