g -四重构象决定了哺乳动物启动子的身份

IF 29 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2025-08-01 DOI:10.1038/s41588-025-02287-y

引用次数: 0

摘要

我们展示了另一种DNA结构，称为g -四联体，作为真核生物启动子的元素。我们的数据表明，它们的功能支持内在核小体排斥，并促进RNA聚合酶II的转录暂停释放。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

G-quadruplexes define promoter identity in mammals

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G-quadruplexes define promoter identity in mammals

We show that alternative DNA structures, called G-quadruplexes, behave as elements of eukaryotic promoters. Our data suggest that they function to support intrinsic nucleosome exclusion and to facilitate transcriptional pause release by RNA polymerase II.

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution