Michelle Carnazza, Robert Werner, Morgan Begley, Nan Yang, Raj Tiwari, Jan Geliebter, Xiu-Min Li
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Notable clinical outcomes include reduction in severity score, reduction across various allergic diseases that demonstrated no toxicity, no severe adverse effects, and are well-tolerated. Immunological outcomes that attribute to this include a switch from Th2-mediated allergic response to a Th1/Treg response, characterized by reduced total and specific IgE, total eosinophil counts, and levels of exotoxin, TNF-a, IL-6, IL-8, IL-5, and IL-4, with elevated levels of IFN-γ and IL-10. For eczema, both multiple and single herbal formulations are common treatment modalities, including internal administration and external herbal baths and creams, whereby both provide substantial beneficial outcomes. For EoE, internally administrated formulations and use of acupuncture have been reported and shown mitigation of allergic responses. In FA, formulations have been studied in clinical trials showing consistent safety, with protection remaining to be established. More advanced development of single herbal compounds may provide an advantage for use in FA treatment. For allergic rhinitis, several multiple herbal formulations and acupuncture have demonstrated improved symptom scores. Similarly, in asthma herbal formulas and acupuncture were highly clinically effective. TCM has demonstrated high safety and efficacy in both preclinical and clinical models of various allergic diseases, including eczema, food allergy, eosinophilic esophagitis, allergic rhinitis, and asthma. Therefore, this scientific evidence suggests that naturally occurring small molecule compounds are promising preventives and therapeutics for pediatric allergic diseases.</p><p><strong>Disclosure: </strong>All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and national/institutional guidelines).</p>","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"33"},"PeriodicalIF":4.6000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313746/pdf/","citationCount":"0","resultStr":"{\"title\":\"Traditional Chinese Medicine for Pediatric Allergic Diseases.\",\"authors\":\"Michelle Carnazza, Robert Werner, Morgan Begley, Nan Yang, Raj Tiwari, Jan Geliebter, Xiu-Min Li\",\"doi\":\"10.1007/s11882-025-01208-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose of review: </strong>There is a clinically important and unmet need for long-term safe and effective preventative and therapeutic options for pediatric allergic diseases. This communication reviewed the use of Traditional Chinese Medicine (TCM) in pediatric allergic disease, including eczema, urticaria, eosinophilic esophagitis (EoE), food allergy (FA), asthma, and allergic rhinitis.</p><p><strong>Recent findings: </strong>Through evaluation of case studies, series, or clinical trials of pediatric allergy patients, or in vitro studies involving samples collected from pediatric allergy patients and in vivo model systems, naturally occurring small molecule compounds' mechanism of action by evidence-based scientific outcomes were elucidated. Notable clinical outcomes include reduction in severity score, reduction across various allergic diseases that demonstrated no toxicity, no severe adverse effects, and are well-tolerated. Immunological outcomes that attribute to this include a switch from Th2-mediated allergic response to a Th1/Treg response, characterized by reduced total and specific IgE, total eosinophil counts, and levels of exotoxin, TNF-a, IL-6, IL-8, IL-5, and IL-4, with elevated levels of IFN-γ and IL-10. For eczema, both multiple and single herbal formulations are common treatment modalities, including internal administration and external herbal baths and creams, whereby both provide substantial beneficial outcomes. For EoE, internally administrated formulations and use of acupuncture have been reported and shown mitigation of allergic responses. In FA, formulations have been studied in clinical trials showing consistent safety, with protection remaining to be established. More advanced development of single herbal compounds may provide an advantage for use in FA treatment. For allergic rhinitis, several multiple herbal formulations and acupuncture have demonstrated improved symptom scores. Similarly, in asthma herbal formulas and acupuncture were highly clinically effective. TCM has demonstrated high safety and efficacy in both preclinical and clinical models of various allergic diseases, including eczema, food allergy, eosinophilic esophagitis, allergic rhinitis, and asthma. 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Traditional Chinese Medicine for Pediatric Allergic Diseases.
Purpose of review: There is a clinically important and unmet need for long-term safe and effective preventative and therapeutic options for pediatric allergic diseases. This communication reviewed the use of Traditional Chinese Medicine (TCM) in pediatric allergic disease, including eczema, urticaria, eosinophilic esophagitis (EoE), food allergy (FA), asthma, and allergic rhinitis.
Recent findings: Through evaluation of case studies, series, or clinical trials of pediatric allergy patients, or in vitro studies involving samples collected from pediatric allergy patients and in vivo model systems, naturally occurring small molecule compounds' mechanism of action by evidence-based scientific outcomes were elucidated. Notable clinical outcomes include reduction in severity score, reduction across various allergic diseases that demonstrated no toxicity, no severe adverse effects, and are well-tolerated. Immunological outcomes that attribute to this include a switch from Th2-mediated allergic response to a Th1/Treg response, characterized by reduced total and specific IgE, total eosinophil counts, and levels of exotoxin, TNF-a, IL-6, IL-8, IL-5, and IL-4, with elevated levels of IFN-γ and IL-10. For eczema, both multiple and single herbal formulations are common treatment modalities, including internal administration and external herbal baths and creams, whereby both provide substantial beneficial outcomes. For EoE, internally administrated formulations and use of acupuncture have been reported and shown mitigation of allergic responses. In FA, formulations have been studied in clinical trials showing consistent safety, with protection remaining to be established. More advanced development of single herbal compounds may provide an advantage for use in FA treatment. For allergic rhinitis, several multiple herbal formulations and acupuncture have demonstrated improved symptom scores. Similarly, in asthma herbal formulas and acupuncture were highly clinically effective. TCM has demonstrated high safety and efficacy in both preclinical and clinical models of various allergic diseases, including eczema, food allergy, eosinophilic esophagitis, allergic rhinitis, and asthma. Therefore, this scientific evidence suggests that naturally occurring small molecule compounds are promising preventives and therapeutics for pediatric allergic diseases.
Disclosure: All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and national/institutional guidelines).
期刊介绍:
The aim of Current Allergy and Asthma Reports is to systematically provide the views of highly selected experts on current advances in the fields of allergy and asthma and highlight the most important papers recently published. All reviews are intended to facilitate the understanding of new advances in science for better diagnosis, treatment, and prevention of allergy and asthma.
We accomplish this aim by appointing international experts in major subject areas across the discipline to review select topics emphasizing recent developments and highlighting important new papers and emerging concepts. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Over a one- to two-year period, readers are updated on all the major advances in allergy and asthma.