路径级收敛:收敛进化的一个未被充分探索的方面。

IF 16.3 2区 生物学 Q1 GENETICS & HEREDITY
Trends in Genetics Pub Date : 2025-10-01 Epub Date: 2025-07-29 DOI:10.1016/j.tig.2025.06.009
Peter K Hoitinga, Siri Birkeland
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引用次数: 0

摘要

进化在遗传水平上可重复的程度仍然是生物学的中心问题。趋同适应可以通过同源基因的突变、同一途径内不同基因的变化或不同分子途径产生。大多数研究都集中在基因水平的趋同上,而对途径水平趋同的普遍性知之甚少。在这里,我们综合了途径水平趋同的理论观点,重点关注一个性状的遗传复杂性和类群之间的分化时间如何影响途径与基因水平趋同的可能性。我们强调方法上的考虑,并认为与系统生物学的整合是推进该领域的关键。我们的目标是激发更多的假设驱动的研究机制和普遍的路径水平的收敛。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pathway-level convergence: an underexplored aspect of convergent evolution.

The extent to which evolution is repeatable at the genetic level remains a central question in biology. Convergent adaptations can arise through mutations in homologous genes, changes in different genes within the same pathways, or distinct molecular routes. Most research has focused on gene-level convergence, whereas relatively little is known about the prevalence of pathway-level convergence. Here, we synthesize theoretical perspectives on pathway-level convergence, focusing on how genetic complexity of a trait and divergence time between taxa shape the likelihood of convergence at the pathway versus gene level. We highlight methodological considerations and argue that integration with systems biology is critical for advancing the field. We aim to stimulate more hypothesis-driven research into the mechanisms and prevalence of pathway-level convergence.

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来源期刊
Trends in Genetics
Trends in Genetics 生物-遗传学
CiteScore
20.90
自引率
0.90%
发文量
160
审稿时长
6-12 weeks
期刊介绍: Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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