利用免疫系统:对癌症疫苗的洞察。

3区 医学 Q2 Medicine
Advances in Immunology Pub Date : 2025-01-01 Epub Date: 2025-03-24 DOI:10.1016/bs.ai.2024.10.006
Sushree Subhadra Acharya, Subhasmita Bhal, Biswajit Das, Chanakya Nath Kundu
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引用次数: 0

摘要

癌症疫苗已经成为对抗癌症的一种很有前途的方法,利用人类免疫系统的非凡能力来识别和消灭癌细胞。这些疫苗经过专门设计,可激活针对恶性细胞的免疫反应,标志着当代研究的重大进展。通过利用免疫系统检测和消除癌细胞的独特能力,这些疫苗在预防和治疗干预方面都有很好的前景。最近的进展为如何针对特定的癌症类型定制这些疫苗,提高其功效并最大限度地减少副作用提供了深刻的见解。这一创新战略具有改变癌症治疗的潜力,为持久有效的治疗提供了新的途径。本章深入探讨了癌症疫苗研究的历史背景,讨论了各种类型的癌症疫苗,它们的作用机制,以及佐剂和递送系统在提高疫苗效力方面的作用。它还涵盖了肿瘤免疫原性,肿瘤细胞如何逃避免疫系统,以及癌症疫苗与其他治疗方法的联合使用。本章旨在阐明癌症疫苗的潜力,以彻底改变癌症治疗和改善患者的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Harnessing the immune system: Insights into cancer vaccines.

Cancer vaccines have become a promising approach in the fight against cancer, harnessing the remarkable capability of the human immune system to recognize and eliminate cancer cells. These vaccines are specifically engineered to activate the immune response against malignant cells, marking a significant advancement in contemporary research. By capitalizing on the unique ability of the immune system to detect and eliminate cancer cells, these vaccines present promising prospects for both prevention and therapeutic intervention. Recent advancements have provided profound insights into how these vaccines can be tailored to target specific cancer types, enhancing their efficacy and minimizing side effects. This innovative strategy holds the potential to transform cancer care, offering new avenues for durable and effective treatments. This chapter delves into the historical context of cancer vaccine research, discussing various types of cancer vaccines, their mechanisms of action, and the role of adjuvants and delivery systems in enhancing vaccine efficacy. It also covers tumor immunogenicity, how tumor cells evade the immune system, and the combined use of cancer vaccines with other treatment approaches. The chapter aims to elucidate the potential of cancer vaccines to revolutionize cancer treatment and improve patient outcomes.

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来源期刊
Advances in Immunology
Advances in Immunology 医学-免疫学
CiteScore
9.90
自引率
0.00%
发文量
13
期刊介绍: Advances in Immunology has provided students and researchers with the latest information in Immunology for over 50 years. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. The articles stress fundamental concepts, but also evaluate the experimental approaches.
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