{"title":"利用免疫系统:对癌症疫苗的洞察。","authors":"Sushree Subhadra Acharya, Subhasmita Bhal, Biswajit Das, Chanakya Nath Kundu","doi":"10.1016/bs.ai.2024.10.006","DOIUrl":null,"url":null,"abstract":"<p><p>Cancer vaccines have become a promising approach in the fight against cancer, harnessing the remarkable capability of the human immune system to recognize and eliminate cancer cells. These vaccines are specifically engineered to activate the immune response against malignant cells, marking a significant advancement in contemporary research. By capitalizing on the unique ability of the immune system to detect and eliminate cancer cells, these vaccines present promising prospects for both prevention and therapeutic intervention. Recent advancements have provided profound insights into how these vaccines can be tailored to target specific cancer types, enhancing their efficacy and minimizing side effects. This innovative strategy holds the potential to transform cancer care, offering new avenues for durable and effective treatments. This chapter delves into the historical context of cancer vaccine research, discussing various types of cancer vaccines, their mechanisms of action, and the role of adjuvants and delivery systems in enhancing vaccine efficacy. It also covers tumor immunogenicity, how tumor cells evade the immune system, and the combined use of cancer vaccines with other treatment approaches. The chapter aims to elucidate the potential of cancer vaccines to revolutionize cancer treatment and improve patient outcomes.</p>","PeriodicalId":50862,"journal":{"name":"Advances in Immunology","volume":"166 ","pages":"1-35"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Harnessing the immune system: Insights into cancer vaccines.\",\"authors\":\"Sushree Subhadra Acharya, Subhasmita Bhal, Biswajit Das, Chanakya Nath Kundu\",\"doi\":\"10.1016/bs.ai.2024.10.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cancer vaccines have become a promising approach in the fight against cancer, harnessing the remarkable capability of the human immune system to recognize and eliminate cancer cells. These vaccines are specifically engineered to activate the immune response against malignant cells, marking a significant advancement in contemporary research. By capitalizing on the unique ability of the immune system to detect and eliminate cancer cells, these vaccines present promising prospects for both prevention and therapeutic intervention. Recent advancements have provided profound insights into how these vaccines can be tailored to target specific cancer types, enhancing their efficacy and minimizing side effects. This innovative strategy holds the potential to transform cancer care, offering new avenues for durable and effective treatments. This chapter delves into the historical context of cancer vaccine research, discussing various types of cancer vaccines, their mechanisms of action, and the role of adjuvants and delivery systems in enhancing vaccine efficacy. It also covers tumor immunogenicity, how tumor cells evade the immune system, and the combined use of cancer vaccines with other treatment approaches. The chapter aims to elucidate the potential of cancer vaccines to revolutionize cancer treatment and improve patient outcomes.</p>\",\"PeriodicalId\":50862,\"journal\":{\"name\":\"Advances in Immunology\",\"volume\":\"166 \",\"pages\":\"1-35\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/bs.ai.2024.10.006\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/bs.ai.2024.10.006","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/24 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Harnessing the immune system: Insights into cancer vaccines.
Cancer vaccines have become a promising approach in the fight against cancer, harnessing the remarkable capability of the human immune system to recognize and eliminate cancer cells. These vaccines are specifically engineered to activate the immune response against malignant cells, marking a significant advancement in contemporary research. By capitalizing on the unique ability of the immune system to detect and eliminate cancer cells, these vaccines present promising prospects for both prevention and therapeutic intervention. Recent advancements have provided profound insights into how these vaccines can be tailored to target specific cancer types, enhancing their efficacy and minimizing side effects. This innovative strategy holds the potential to transform cancer care, offering new avenues for durable and effective treatments. This chapter delves into the historical context of cancer vaccine research, discussing various types of cancer vaccines, their mechanisms of action, and the role of adjuvants and delivery systems in enhancing vaccine efficacy. It also covers tumor immunogenicity, how tumor cells evade the immune system, and the combined use of cancer vaccines with other treatment approaches. The chapter aims to elucidate the potential of cancer vaccines to revolutionize cancer treatment and improve patient outcomes.
期刊介绍:
Advances in Immunology has provided students and researchers with the latest information in Immunology for over 50 years. You can continue to rely on Advances in Immunology to provide you with critical reviews that examine subjects of vital importance to the field through summary and evaluation of current knowledge and research. The articles stress fundamental concepts, but also evaluate the experimental approaches.