基底膜在肺发育、疾病和修复中的作用。

IF 4.8 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology Pub Date : 2025-07-28 DOI:10.1016/j.matbio.2025.07.007

Matilda Thuringer , Roy Zent , Rachel Lennon , Erin J. Plosa

{"title":"基底膜在肺发育、疾病和修复中的作用。","authors":"Matilda Thuringer , Roy Zent , Rachel Lennon , Erin J. Plosa","doi":"10.1016/j.matbio.2025.07.007","DOIUrl":null,"url":null,"abstract":"<div><div>The primary function of the respiratory system is the exchange of oxygen and carbon dioxide across the alveolar-capillary barrier in the distal lung. This structure is composed of alveolar epithelial cells (type 1 and type 2) and capillary endothelial cells, separated by a thin, fused alveolar basement membrane. The developmental programming that creates this specialized niche is largely unexplored and the role of lung basement membranes in respiratory disease pathogenesis and repair remains an emerging field of study. Thus, in this review, we discuss the distribution, composition, and function of the alveolar basement membrane, as well as the other three lung basement membranes that support the airway epithelium, airway smooth muscles, and the endothelium of the macrovasculature in lung development and disease.</div></div>","PeriodicalId":49851,"journal":{"name":"Matrix Biology","volume":"140 ","pages":"Pages 123-132"},"PeriodicalIF":4.8000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Basement membranes in lung development, disease, and repair\",\"authors\":\"Matilda Thuringer , Roy Zent , Rachel Lennon , Erin J. Plosa\",\"doi\":\"10.1016/j.matbio.2025.07.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The primary function of the respiratory system is the exchange of oxygen and carbon dioxide across the alveolar-capillary barrier in the distal lung. This structure is composed of alveolar epithelial cells (type 1 and type 2) and capillary endothelial cells, separated by a thin, fused alveolar basement membrane. The developmental programming that creates this specialized niche is largely unexplored and the role of lung basement membranes in respiratory disease pathogenesis and repair remains an emerging field of study. Thus, in this review, we discuss the distribution, composition, and function of the alveolar basement membrane, as well as the other three lung basement membranes that support the airway epithelium, airway smooth muscles, and the endothelium of the macrovasculature in lung development and disease.</div></div>\",\"PeriodicalId\":49851,\"journal\":{\"name\":\"Matrix Biology\",\"volume\":\"140 \",\"pages\":\"Pages 123-132\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Matrix Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0945053X25000666\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Matrix Biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0945053X25000666","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

呼吸系统的主要功能是通过远端肺的肺泡-毛细血管屏障交换氧气和二氧化碳。该结构由肺泡上皮细胞（1型和2型）和毛细血管内皮细胞组成，由一层薄薄的融合肺泡基底膜隔开。创造这种特殊生态位的发育程序在很大程度上尚未被探索，肺基底膜在呼吸系统疾病发病机制和修复中的作用仍然是一个新兴的研究领域。因此，在这篇综述中，我们讨论了肺泡基底膜的分布、组成和功能，以及在肺发育和疾病中支持气道上皮、气道平滑肌和大血管内皮的其他三种肺基底膜。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Basement membranes in lung development, disease, and repair

The primary function of the respiratory system is the exchange of oxygen and carbon dioxide across the alveolar-capillary barrier in the distal lung. This structure is composed of alveolar epithelial cells (type 1 and type 2) and capillary endothelial cells, separated by a thin, fused alveolar basement membrane. The developmental programming that creates this specialized niche is largely unexplored and the role of lung basement membranes in respiratory disease pathogenesis and repair remains an emerging field of study. Thus, in this review, we discuss the distribution, composition, and function of the alveolar basement membrane, as well as the other three lung basement membranes that support the airway epithelium, airway smooth muscles, and the endothelium of the macrovasculature in lung development and disease.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Matrix Biology 生物-生化与分子生物学

CiteScore

11.40

自引率

4.30%

发文量

审稿时长

45 days

期刊介绍： Matrix Biology (established in 1980 as Collagen and Related Research) is a cutting-edge journal that is devoted to publishing the latest results in matrix biology research. We welcome articles that reside at the nexus of understanding the cellular and molecular pathophysiology of the extracellular matrix. Matrix Biology focusses on solving elusive questions, opening new avenues of thought and discovery, and challenging longstanding biological paradigms.