{"title":"猪耳咽管软骨的离体机电重塑。","authors":"Byungwoo Yoon, Soo-Kweon Koo, Moo-Jin Baek, Il-Woo Lee, Se-Joon Oh, Soo-Keun Kong","doi":"10.7874/jao.2025.00157","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>The Eustachian tube cartilage (ETC) is the cartilaginous frame of the Eustachian tube (ET), which plays a pivotal role in its function. Existing treatments for ET dysfunction (ETD) are primarily based on mechanical deformation. Electromechanical reshaping (EMR) is a novel method used to reshape the cartilage into the desired form by applying an electric current using strategically placed needles for mechanical deformation. In this study, EMR was evaluated for its ability to reshape the ETC.</p><p><strong>Materials and methods: </strong>A total of 84 ETCs were harvested from 42 post-mortem porcine crania and randomly divided into control and experimental (EMR) groups. To reshape the ETC, the control ETCs were subjected to a mechanical force, whereas the experimental group was subjected to the same force and current of 3, 4, or 5 V for 2 or 3 min. Changes in shape were assessed by measuring the contour angles using digital photographs.</p><p><strong>Results: </strong>In the analysis of the contour angle, ETC post-EMR for 2 min at ≥4 V demonstrated significant reshaping relative to the control group (p<0.05).</p><p><strong>Conclusions: </strong>EMR can be used to reshape the ETCs ex vivo. Future experiments with well-designed ex vivo and in vivo conditions are required to develop novel therapeutic options for ETD.</p>","PeriodicalId":44886,"journal":{"name":"Journal of Audiology and Otology","volume":"29 3","pages":"219-225"},"PeriodicalIF":1.4000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313434/pdf/","citationCount":"0","resultStr":"{\"title\":\"Electromechanical Reshaping of Porcine Eustachian Tube Cartilage Ex Vivo.\",\"authors\":\"Byungwoo Yoon, Soo-Kweon Koo, Moo-Jin Baek, Il-Woo Lee, Se-Joon Oh, Soo-Keun Kong\",\"doi\":\"10.7874/jao.2025.00157\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objectives: </strong>The Eustachian tube cartilage (ETC) is the cartilaginous frame of the Eustachian tube (ET), which plays a pivotal role in its function. Existing treatments for ET dysfunction (ETD) are primarily based on mechanical deformation. Electromechanical reshaping (EMR) is a novel method used to reshape the cartilage into the desired form by applying an electric current using strategically placed needles for mechanical deformation. In this study, EMR was evaluated for its ability to reshape the ETC.</p><p><strong>Materials and methods: </strong>A total of 84 ETCs were harvested from 42 post-mortem porcine crania and randomly divided into control and experimental (EMR) groups. To reshape the ETC, the control ETCs were subjected to a mechanical force, whereas the experimental group was subjected to the same force and current of 3, 4, or 5 V for 2 or 3 min. Changes in shape were assessed by measuring the contour angles using digital photographs.</p><p><strong>Results: </strong>In the analysis of the contour angle, ETC post-EMR for 2 min at ≥4 V demonstrated significant reshaping relative to the control group (p<0.05).</p><p><strong>Conclusions: </strong>EMR can be used to reshape the ETCs ex vivo. Future experiments with well-designed ex vivo and in vivo conditions are required to develop novel therapeutic options for ETD.</p>\",\"PeriodicalId\":44886,\"journal\":{\"name\":\"Journal of Audiology and Otology\",\"volume\":\"29 3\",\"pages\":\"219-225\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313434/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Audiology and Otology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7874/jao.2025.00157\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Audiology and Otology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7874/jao.2025.00157","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/18 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Electromechanical Reshaping of Porcine Eustachian Tube Cartilage Ex Vivo.
Background and objectives: The Eustachian tube cartilage (ETC) is the cartilaginous frame of the Eustachian tube (ET), which plays a pivotal role in its function. Existing treatments for ET dysfunction (ETD) are primarily based on mechanical deformation. Electromechanical reshaping (EMR) is a novel method used to reshape the cartilage into the desired form by applying an electric current using strategically placed needles for mechanical deformation. In this study, EMR was evaluated for its ability to reshape the ETC.
Materials and methods: A total of 84 ETCs were harvested from 42 post-mortem porcine crania and randomly divided into control and experimental (EMR) groups. To reshape the ETC, the control ETCs were subjected to a mechanical force, whereas the experimental group was subjected to the same force and current of 3, 4, or 5 V for 2 or 3 min. Changes in shape were assessed by measuring the contour angles using digital photographs.
Results: In the analysis of the contour angle, ETC post-EMR for 2 min at ≥4 V demonstrated significant reshaping relative to the control group (p<0.05).
Conclusions: EMR can be used to reshape the ETCs ex vivo. Future experiments with well-designed ex vivo and in vivo conditions are required to develop novel therapeutic options for ETD.
期刊介绍：
Journal of Audiology and Otology (JAO) (formerly known as Korean Journal of Audiology) aims to publish the most advanced findings for all aspects of the auditory and vestibular system and diseases of the ear using state-of-the-art techniques and analyses. The journal covers recent trends related to the topics of audiology, otology, and neurotology conducted by professionals, with the goal of providing better possible treatment to people of all ages, from infants to the elderly, who suffer from auditory and/or vestibular disorders and thus, improving their quality of life. This journal encourages the submission of review papers about current professional issues, research papers presenting a scientific base and clinical application, and case papers with unique reports or clinical trials. We also invite letters to the editor and papers related to the manufacture and distribution of medical devices. This journal provides integrated views from otologists, audiologists, and other healthcare practitioners, offering readers high quality scientific and clinical information. This peer-reviewed and open access journal has been the official journal of the Korean Audiological Society since 1997 and of both the Korean Audiological Society and the Korean Otological Society since 2017. It is published in English four times a year in January, April, July, and October.
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