释放铁下垂、自噬和线粒体动力学作为癌症治疗新模式的潜力。

IF 3.2 Q3 ONCOLOGY
Tanha Ashok Rana, Akhilesh Prajapati
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引用次数: 0

摘要

癌症治疗的新方法越来越强调创新的生物过程,如铁下垂、自噬和线粒体动力学。以铁依赖性脂质过氧化为特征的上睑下垂已成为一种很有前途的策略,用于治疗侵袭性和转移性癌症,包括肺癌、乳腺癌、前列腺癌、胰腺癌和结肠直肠癌。自噬是一种细胞降解机制,在癌症中起着双重作用——它可以通过清除受损的细胞成分来抑制肿瘤的发展,或者在应激条件下支持肿瘤的生长。线粒体动力学,包括连续的裂变和融合过程,在各种类型的人类癌症中经常被破坏,导致代谢改变,治疗抵抗和转移。这些干扰使它们成为创新治疗的有利目标。本文综述了铁下垂作为一种新的细胞死亡形式,重点关注其生物学途径以及与线粒体功能障碍和自噬的联系。了解这三种机制在复杂的癌症生物学中的相互作用,可以为癌症治疗提供更全面和有效的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Unleashing the potential of ferroptosis, autophagy, and mitochondrial dynamics as emerging modalities in cancer treatment.

Unleashing the potential of ferroptosis, autophagy, and mitochondrial dynamics as emerging modalities in cancer treatment.

Unleashing the potential of ferroptosis, autophagy, and mitochondrial dynamics as emerging modalities in cancer treatment.

Unleashing the potential of ferroptosis, autophagy, and mitochondrial dynamics as emerging modalities in cancer treatment.

New approaches in cancer treatment are increasingly emphasizing innovative biological processes such as ferroptosis, autophagy, and mitochondrial dynamics. Ferroptosis, characterized by iron-dependent lipid peroxidation, has emerged as a promising strategy for targeting aggressive and metastatic cancers including those of the lung, breast, prostate, pancreas, and colorectal regions. Autophagy, a cellular degradation mechanism, plays a dual role in cancer-it can inhibit tumor development by clearing damaged cellular components or, paradoxically, support tumor growth under stressful conditions. Mitochondrial dynamics, encompassing the continuous processes of fission and fusion, are often disrupted in various types of human cancers, leading to altered metabolism, therapy resistance, and metastasis. These disruptions make them favorable targets for innovative treatments. This review highlights ferroptosis as a novel form of cell death, focusing on its biological pathways and connections with mitochondrial dysfunction and autophagy. Understanding the interplay among these three mechanisms in the complex biology of cancer could provide a more comprehensive and effective approach to cancer therapy.

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来源期刊
自引率
0.00%
发文量
585
期刊介绍: The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.
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