Ibtehaj Tariq, Qurat Ul Ain Iftikhar, Abdulqadir J Nashwan
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Proton pump inhibitors and mortality in patients with cancer: Unraveling the complex link.
Proton pump inhibitors (PPIs) are widely utilized in oncology to treat gastroesophageal reflux disease, peptic ulcer disease, and chemotherapy-induced mucosal injury. Emerging evidence has suggested that prolonged use of PPIs is associated with increased mortality in patients with cancer. The findings of Krishnan et al are proof of this but need to be considered cautiously due to potential confounding factors. This letter raised important methodological concerns, including confounding by indication, reverse causality, and polypharmacy that can influence the observed association. While PPIs are important in oncology, their advantages and disadvantages should be weighed judiciously by clinicians. Future prospective studies with robust analytical approaches will be required to ascertain more definite causality.
期刊介绍:
The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.