结直肠癌伴肝转移的治疗现状及进展。

IF 3.2 Q3 ONCOLOGY
Wei-Xing Liu, Chuang Jiang, Jia-Xin Li
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引用次数: 0

摘要

结直肠癌的发病率逐渐升高,多数患者在初诊时被诊断为远处转移,肝脏是最常见的转移部位。与大多数恶性肿瘤不同的是,如果原发肿瘤和肝转移灶都进行手术切除,远处转移的患者仍然可以获得良好的预后。随着全身治疗的进步,许多最初无法切除的结直肠癌肝转移患者可以通过全身治疗实现转化治疗,从而获得手术的机会。然而,在术前和术后系统治疗的时机、是否应采用新辅助治疗、同时手术还是分阶段手术的选择等几个问题上仍未达成共识。本文旨在系统介绍结直肠癌肝转移的治疗现状,并重点介绍几个尚未解决的争议问题,为结直肠癌肝转移的诊断和治疗提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current status and advances in the treatment of colorectal cancer with liver metastases.

The incidence of colorectal cancer is gradually increasing, and a majority of patients are diagnosed with distant metastases at the time of initial diagnosis, with the liver being the most common site of metastasis. Unlike most malignant tumors, patients with distant metastases can still achieve favorable prognoses if both the primary tumor and liver metastases are surgically resected. With advances in systemic therapies, many patients with initially unresectable liver metastases from colorectal cancer can undergo systemic treatment to achieve conversion therapy, thereby gaining the opportunity for surgery. However, there is still no consensus on several issues, including the timing of systemic therapy before and after surgery, whether neoadjuvant therapy should be employed, and the choice between simultaneous or staged surgeries. This review aims to systematically describe the current treatment landscape for colorectal cancer with liver metastases and highlight several unresolved controversial issues, providing valuable insights for the diagnosis and treatment of colorectal liver metastases.

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来源期刊
自引率
0.00%
发文量
585
期刊介绍: The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.
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