胆囊癌的早期检测:现状与未来展望。

IF 3.2 Q3 ONCOLOGY
Yajnadatta Sarangi, Ashok Kumar
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引用次数: 0

摘要

胆囊癌(GBC)仍然是一种高度侵袭性的疾病,总体5年生存率为15%-20%。它在非常早期的无症状性质和非特异性临床表现对及时发现提出了重大挑战。因此,GBC往往出现较晚,使其成为最具挑战性的癌症之一。手术为长期生存提供了最好的机会;然而,只有10%的GBC患者适合进行前期切除,大多数患者表现为局部晚期或转移期。此外,GBC通常对化疗和放疗具有耐药性,限制了全身治疗的有效性。因此,早期诊断对于通过手术切除提供最佳治疗和改善预后至关重要。成像技术、生物标志物发现和分子诊断的最新进展为提高检出率提供了有希望的途径。虽然非侵入性,但大多数缺乏特异性,而且大多数不能作为早期诊断工具。本文综述了GBC早期检测策略的现状,解决了现有方法的局限性,并探讨了新兴的诊断工具和技术,以及未来如何利用它们进行早期检测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Early detection of gallbladder cancer: Current status and future perspectives.

Early detection of gallbladder cancer: Current status and future perspectives.

Early detection of gallbladder cancer: Current status and future perspectives.

Gall bladder cancer (GBC) remains a highly aggressive disease, with an overall 5-year dismal survival rate of 15%-20%. Its asymptomatic nature in very early stages and non-specific clinical presentations pose significant challenges to timely detection. Consequently, GBC often presents late, making it one of the most challenging cancers to manage. Surgery offers the best chance for long-term survival; however, only 10% of GBC patients are candidates for upfront resection, with the majority presenting in locally advanced or metastatic stages. Furthermore, GBC is generally resistant to chemotherapy and radiotherapy, limiting the effectiveness of systemic therapy. Therefore, early diagnosis is crucial to offer the best treatment through surgical resection and to improve the outcome. Recent advancements in imaging technologies, biomarker discovery, and molecular diagnostics offer promising avenues for enhancing detection rates. Though non-invasive, most of them lack specificity, and the majority fail as an early diagnostic tool. This review examines the current status of early detection strategies for GBC, addresses the limitations of existing approaches, and explores the newer emerging diagnostic tools and techniques and how they can be exploited in future for its early detection.

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来源期刊
自引率
0.00%
发文量
585
期刊介绍: The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.
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