禁止物作为线粒体稳态守护者的作用。

IF 4.5 3区生物学 Q2 CELL BIOLOGY

Mitochondrion Pub Date : 2025-07-28 DOI:10.1016/j.mito.2025.102075

Sabrina Champsi, David A. Hood

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引用次数: 0

摘要

线粒体是复杂的细胞器，对维持细胞稳态至关重要。这一调控的核心是禁止蛋白（PHBs），这是一组涉及多种线粒体质量控制途径的新蛋白质，包括蛋白质折叠、生物发生和线粒体自噬。PHBs介导多种细胞反应，包括细胞存活和肌肉形成，表明它们的作用是复杂和多方面的。虽然有证据表明PHBs促进线粒体稳态，但其确切的作用机制尚不清楚。阐明驱动phb介导的适应的精确机制将最终促进针对以线粒体扰动为特征的年龄相关疾病的治疗策略的发展。

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Role of Prohibitins as Guardians of mitochondrial homeostasis

Mitochondria are complex organelles critical to the maintenance of cellular homeostasis. Central to this regulation are Prohibitins (PHBs), a novel set of proteins involved in several mitochondrial quality control pathways, including protein folding, biogenesis, and mitophagy. PHBs mediate various cellular responses including cell survival and myogenesis, suggesting that their roles are intricate and multifaceted. While evidence suggests that PHBs facilitate mitochondrial homeostasis, their exact mechanism of action remains unclear. Elucidating the precise mechanisms driving PHB-mediated adaptations will ultimately enable the development of therapeutic strategies aimed towards the treatment of age-related diseases, characterized by mitochondrial perturbations.

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来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.