Enzo Pérez-Valenzuela, Victor Azocar, Andrea Gräber-Martinez, Alvaro Vergés, José Fuentealba Evans
{"title":"基线冲动性对CB1激动作用对冲动性选择的急性和持续性影响的调节作用。","authors":"Enzo Pérez-Valenzuela, Victor Azocar, Andrea Gräber-Martinez, Alvaro Vergés, José Fuentealba Evans","doi":"10.1177/02698811251355603","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Impulsivity may be defined as a heterogeneous construct characterized by difficulties in inhibiting actions and premature decision-making. Although a high level of impulsivity is recognized as a risk factor for cannabis use disorder, the effects of cannabinoids on impulsive choices have been less explored.</p><p><strong>Aims: </strong>This study aimed to determine the acute and persistent effects of CB<sub>1/2</sub> agonism on impulsive choice in rats using a delay-discounting task (DDT).</p><p><strong>Methods: </strong>Trained adult male Sprague-Dawley rats were injected with either vehicle or increasing doses (0.1, 1, and 5 mg/kg) of the CB<sub>1/2</sub> agonist WIN 55212-2 and tested in the DDT.</p><p><strong>Results: </strong>Our results showed that the effect of WIN55212-2 correlated with baseline impulsivity and reduced impulsivity in rats classified as high impulsive, while no effect was observed in rats classified as low impulsivity. Two weeks after the last WIN55212-2 injection, the rats were injected with vehicle and re-exposed to DDT. Rats classified as high impulsive maintained a significantly high AUC<sub>log</sub> value, suggesting a long-lasting effect of WIN 55212-2. Finally, the CB<sub>1</sub> receptor antagonist rimonabant (1 mg/kg) reversed the effect of repeated treatment with WIN55212-2 on impulsivity in the high-impulsive population, suggesting an active role of the CB<sub>1/2</sub> receptor in the persistent effect of WIN55212-2.</p><p><strong>Conclusions: </strong>Our results suggest a potential benefit of CB<sub>1/2</sub> agonism in vulnerable subpopulations with high levels of impulsivity. To maximize therapeutic benefits and minimize potential iatrogenic effects, assessing choice impulsivity and other variables is essential, aligning with personalized medicine principles to effectively tailor interventions.</p>","PeriodicalId":16892,"journal":{"name":"Journal of Psychopharmacology","volume":" ","pages":"2698811251355603"},"PeriodicalIF":5.5000,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"\\\"Modulatory role of baseline impulsivity on the acute and persistent effects of CB<sub>1</sub> agonism on impulsive choice\\\".\",\"authors\":\"Enzo Pérez-Valenzuela, Victor Azocar, Andrea Gräber-Martinez, Alvaro Vergés, José Fuentealba Evans\",\"doi\":\"10.1177/02698811251355603\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Impulsivity may be defined as a heterogeneous construct characterized by difficulties in inhibiting actions and premature decision-making. Although a high level of impulsivity is recognized as a risk factor for cannabis use disorder, the effects of cannabinoids on impulsive choices have been less explored.</p><p><strong>Aims: </strong>This study aimed to determine the acute and persistent effects of CB<sub>1/2</sub> agonism on impulsive choice in rats using a delay-discounting task (DDT).</p><p><strong>Methods: </strong>Trained adult male Sprague-Dawley rats were injected with either vehicle or increasing doses (0.1, 1, and 5 mg/kg) of the CB<sub>1/2</sub> agonist WIN 55212-2 and tested in the DDT.</p><p><strong>Results: </strong>Our results showed that the effect of WIN55212-2 correlated with baseline impulsivity and reduced impulsivity in rats classified as high impulsive, while no effect was observed in rats classified as low impulsivity. Two weeks after the last WIN55212-2 injection, the rats were injected with vehicle and re-exposed to DDT. Rats classified as high impulsive maintained a significantly high AUC<sub>log</sub> value, suggesting a long-lasting effect of WIN 55212-2. Finally, the CB<sub>1</sub> receptor antagonist rimonabant (1 mg/kg) reversed the effect of repeated treatment with WIN55212-2 on impulsivity in the high-impulsive population, suggesting an active role of the CB<sub>1/2</sub> receptor in the persistent effect of WIN55212-2.</p><p><strong>Conclusions: </strong>Our results suggest a potential benefit of CB<sub>1/2</sub> agonism in vulnerable subpopulations with high levels of impulsivity. To maximize therapeutic benefits and minimize potential iatrogenic effects, assessing choice impulsivity and other variables is essential, aligning with personalized medicine principles to effectively tailor interventions.</p>\",\"PeriodicalId\":16892,\"journal\":{\"name\":\"Journal of Psychopharmacology\",\"volume\":\" \",\"pages\":\"2698811251355603\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Psychopharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/02698811251355603\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Psychopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/02698811251355603","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
"Modulatory role of baseline impulsivity on the acute and persistent effects of CB1 agonism on impulsive choice".
Background: Impulsivity may be defined as a heterogeneous construct characterized by difficulties in inhibiting actions and premature decision-making. Although a high level of impulsivity is recognized as a risk factor for cannabis use disorder, the effects of cannabinoids on impulsive choices have been less explored.
Aims: This study aimed to determine the acute and persistent effects of CB1/2 agonism on impulsive choice in rats using a delay-discounting task (DDT).
Methods: Trained adult male Sprague-Dawley rats were injected with either vehicle or increasing doses (0.1, 1, and 5 mg/kg) of the CB1/2 agonist WIN 55212-2 and tested in the DDT.
Results: Our results showed that the effect of WIN55212-2 correlated with baseline impulsivity and reduced impulsivity in rats classified as high impulsive, while no effect was observed in rats classified as low impulsivity. Two weeks after the last WIN55212-2 injection, the rats were injected with vehicle and re-exposed to DDT. Rats classified as high impulsive maintained a significantly high AUClog value, suggesting a long-lasting effect of WIN 55212-2. Finally, the CB1 receptor antagonist rimonabant (1 mg/kg) reversed the effect of repeated treatment with WIN55212-2 on impulsivity in the high-impulsive population, suggesting an active role of the CB1/2 receptor in the persistent effect of WIN55212-2.
Conclusions: Our results suggest a potential benefit of CB1/2 agonism in vulnerable subpopulations with high levels of impulsivity. To maximize therapeutic benefits and minimize potential iatrogenic effects, assessing choice impulsivity and other variables is essential, aligning with personalized medicine principles to effectively tailor interventions.
期刊介绍：
The Journal of Psychopharmacology is a fully peer-reviewed, international journal that publishes original research and review articles on preclinical and clinical aspects of psychopharmacology. The journal provides an essential forum for researchers and practicing clinicians on the effects of drugs on animal and human behavior, and the mechanisms underlying these effects. The Journal of Psychopharmacology is truly international in scope and readership.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
