帕金森痴呆症的进展不受阿尔茨海默病或帕金森病的遗传风险变异的调节。

IF 5 3区医学 Q2 NEUROSCIENCES

Journal of Parkinson's disease Pub Date : 2025-07-30 DOI:10.1177/1877718X251356512

Kayenat Parveen, J Alexander Ross, Hendrik van der Wurp, Monika Balzer-Geldsetzer, Daniela Berg, Günther Deuschl, Thomas Gasser, Rüdiger Hilker-Roggendorf, Elke Kalbe, Inga Liepelt-Scarfone, Brit Mollenhauer, Oliver Riedel, Sandra Röske, Jörg B Schulz, Annika Spottke, Alexander Storch, Claudia Trenkwalder, Jan Kassubek, Karsten Witt, Richard Dodel, Ullrich Wüllner, Alfredo Ramirez, Maria Carolina Dalmasso

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引用次数: 0

摘要

帕金森病（PD）以运动症状为特征，通常伴有轻度认知障碍（PD- mci），影响多达50%的患者，并伴有PD痴呆（PDD）。遗传因素可能影响这一进展，但潜在的机制尚不清楚。本研究利用多基因风险评分（PRS）研究影响PD-MCI向PDD进展的遗传因素。使用LANDSCAPE研究的数据进行了全基因组关联研究（GWAS）。多变量Cox回归、Kaplan-Meier生存分析和一致性统计评估了PRS与PDD进展之间的关系。未发现PD PRS与PDD发病风险之间存在显著关联。

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Progression to Parkinson's dementia is not modulated by genetic risk variants for Alzheimer's or Parkinson's disease.

Parkinson's disease (PD) is marked by motor symptoms and often accompanied by mild cognitive impairment (PD-MCI), affecting up to 50% of patients and preceding PD dementia (PDD). Genetic factors may influence this progression, yet the underlying mechanisms remain unclear. This study investigated genetic factors influencing the progression from PD-MCI to PDD using polygenic risk scores (PRS). A genome-wide association study (GWAS) was conducted using data from the LANDSCAPE study. Multivariable Cox regression, Kaplan-Meier survival analysis, and concordance statistics assessed the relationship between PRS and PDD progression. No significant association was found between PD PRS and the risk of developing PDD.

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来源期刊

Journal of Parkinson's disease NEUROSCIENCES-

CiteScore

8.40

自引率

5.80%

发文量

338

审稿时长

>12 weeks

期刊介绍： The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.