Mohammad Ali Hojjati Kermani, Farhang Hameed Awlqadr, Sepide Talebi, Sanaz Mehrabani, Donny M Camera, Reza Bagheri, Fariborz Poorbaferani, Seyed Mojtaba Ghoreishy, Parsa Amirian, Mahsa Zarpoosh, Sajjad Moradi
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Relative risks (RRs) and 95% confidence intervals (CIs) were pooled using a random-effects model. Study quality and the presence of publication bias were assessed using the Newcastle-Ottawa Scale, Egger's regression asymmetry test, and Begg's rank correlation test.</p><p><strong>Results: </strong>Data from 29 studies were included. Cohort studies showed that higher UPF intake was significantly associated with an increased risk of frailty (RR = 1.40; 95% CI 1.25-1.58; I<sup>2</sup> = 83.0%; p < 0.001; n = 11), but not with LMS. In contrast, cross-sectional studies indicated that higher UPF intake was significantly associated with an increased risk of LMS (RR = 1.13; 95% CI 1.06-1.20; I<sup>2</sup> = 0.0%; p < 0.001; n = 5), but not with frailty, sarcopenia, or LMM. Furthermore, a 100 g increase in UPF intake was associated with a 3% higher risk of frailty (RR = 1.03; 95% CI 1.01-1.06; I<sup>2</sup> = 85.1%; p = 0.016; n = 5). Non-linear dose-response analysis showed a positive linear association between UPF intake and frailty risk (P_non-linearity = 0.807; P_dose-response < 0.001; n = 5).</p><p><strong>Conclusion: </strong>Higher UPF intake was associated with an increased risk of frailty in cohort studies and with low muscle strength in cross-sectional studies. 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引用次数: 0
摘要
目的：长期过量摄入超加工食品（upf）与各种代谢状况有关；然而，它对老年人骨骼肌质量和功能的影响尚不清楚。因此，我们进行了这项研究，以检查UPF摄入量与年龄相关的肌肉结果之间的关系，包括虚弱、肌肉减少症、低肌肉质量（LMM）和/或低肌肉力量（LMS）。方法：系统检索截至2024年11月1日的ISI Web of Science、LILACS、PubMed/MEDLINE、Scopus数据库。使用随机效应模型汇总相对风险（RRs）和95%置信区间（ci）。采用Newcastle-Ottawa量表、Egger's回归不对称检验和Begg's秩相关检验评估研究质量和发表偏倚的存在。结果：纳入了29项研究的数据。队列研究表明，较高的UPF摄入量与虚弱风险增加显著相关(RR = 1.40；95% ci 1.25-1.58；i2 = 83.0%；p 2 = 0.0%；p 2 = 85.1%；p = 0.016；n = 5)。非线性剂量-反应分析显示，UPF摄入量与脆弱风险呈正线性相关(p_非线性= 0.807；结论：在队列研究中，较高的UPF摄入量与虚弱的风险增加有关，在横断面研究中与肌肉力量低有关。这些发现表明，经常食用upf可能会对肌肉健康产生负面影响，可能会损害老年人的生活质量和独立性。
The association of ultra-processed food intake on age-related muscle conditions: a systematic review and dose-response meta-analysis with meta-regression.
Objectives: Chronic excessive intake of ultra-processed foods (UPFs) has been linked to various metabolic conditions; however, its impact on skeletal muscle mass and function in older adults remains unclear. Therefore, we conducted this study to examine the association between UPF intake and age-related muscle outcomes, including frailty, sarcopenia, low muscle mass (LMM), and/or low muscle strength (LMS).
Methods: A systematic search was conducted in ISI Web of Science, LILACS, PubMed/MEDLINE, and Scopus without restrictions up to November 1, 2024. Relative risks (RRs) and 95% confidence intervals (CIs) were pooled using a random-effects model. Study quality and the presence of publication bias were assessed using the Newcastle-Ottawa Scale, Egger's regression asymmetry test, and Begg's rank correlation test.
Results: Data from 29 studies were included. Cohort studies showed that higher UPF intake was significantly associated with an increased risk of frailty (RR = 1.40; 95% CI 1.25-1.58; I2 = 83.0%; p < 0.001; n = 11), but not with LMS. In contrast, cross-sectional studies indicated that higher UPF intake was significantly associated with an increased risk of LMS (RR = 1.13; 95% CI 1.06-1.20; I2 = 0.0%; p < 0.001; n = 5), but not with frailty, sarcopenia, or LMM. Furthermore, a 100 g increase in UPF intake was associated with a 3% higher risk of frailty (RR = 1.03; 95% CI 1.01-1.06; I2 = 85.1%; p = 0.016; n = 5). Non-linear dose-response analysis showed a positive linear association between UPF intake and frailty risk (P_non-linearity = 0.807; P_dose-response < 0.001; n = 5).
Conclusion: Higher UPF intake was associated with an increased risk of frailty in cohort studies and with low muscle strength in cross-sectional studies. These findings suggest that regular consumption of UPFs may negatively affect muscle health, potentially impairing quality of life and independence in older adults.
期刊介绍：
Journal of Health, Population and Nutrition brings together research on all aspects of issues related to population, nutrition and health. The journal publishes articles across a broad range of topics including global health, maternal and child health, nutrition, common illnesses and determinants of population health.
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