日本首例人感染blactx - m -14阳性水痘克雷伯菌病例。

IF 1.1 4区医学 Q4 INFECTIOUS DISEASES

Japanese journal of infectious diseases Pub Date : 2025-07-31 DOI:10.7883/yoken.JJID.2025.006

Yoshihiko Ogawa, Yuki Suzuki, Tatsuki Mizobe, Kenya Murata, Kohei Hasegawa, Ryuichi Nakano, Kei Kasahara, Hisakazu Yano

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引用次数: 0

摘要

经常被误认为肺炎克雷伯菌的水痘克雷伯菌，正逐渐被认为是一种病原体。本研究报告了日本第一例携带blaCTX-M-14的人感染天花分枝杆菌病例。MALDI飞行时间质谱法证实从尿液和血液培养中分离的临床分离株为天花克雷伯氏菌。用头孢美唑成功治疗了感染。全基因组测序鉴定出blaCTX-M-14在一个8066 bp的质粒中。鉴于日本广谱β -内酰胺酶阳性的天花克雷伯氏菌感染罕见，本病例突出了准确识别和监测多重耐药病原体的重要性。

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First human infection case of bla_CTX-M-14-positive Klebsiella variicola in Japan.

Klebsiella variicola, often misidentified as Klebsiella pneumoniae, is gaining recognition as a pathogen. This study reports the first human case of infection with K. variicola harboring bla_CTX-M-14 in Japan. MALDI time-of-flight mass spectrometry was used to confirm that clinical isolates from urine and blood cultures were K. variicola. The infection was successfully treated with cefmetazole. Whole-genome sequencing identified bla_CTX-M-14 in an 8,066 bp plasmid. Given the rarity of extended-spectrum beta-lactamase-positive K. variicola infections in Japan, this case highlights the importance of accurately identifying and monitoring multidrug-resistant pathogens.

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来源期刊

Japanese journal of infectious diseases 医学-传染病学

CiteScore

4.50

自引率

4.50%

发文量

172

审稿时长

2 months

期刊介绍： Japanese Journal of Infectious Diseases (JJID), an official bimonthly publication of National Institute of Infectious Diseases, Japan, publishes papers dealing with basic research on infectious diseases relevant to humans in the fields of bacteriology, virology, mycology, parasitology, medical entomology, vaccinology, and toxinology. Pathology, immunology, biochemistry, and blood safety related to microbial pathogens are among the fields covered. Sections include: original papers, short communications, epidemiological reports, methods, laboratory and epidemiology communications, letters to the editor, and reviews.