代谢状态和代谢物作为动脉粥样硬化驱动因素的循环。

IF 4.6 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Current opinion in lipidology Pub Date : 2025-10-01 Epub Date: 2025-07-30 DOI:10.1097/MOL.0000000000001004
Franziska Krautter, Edward A Fisher
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引用次数: 0

摘要

综述目的:心血管疾病(cvd)是世界范围内死亡的主要原因。众所周知,肥胖、血脂异常和糖尿病是心血管疾病的主要危险因素,但观察性临床研究表明,体重、循环低密度脂蛋白胆固醇(LDL-C)或葡萄糖水平的变化进一步增加了这种风险。然而,由于代谢循环导致心血管疾病风险增加的潜在机制尚不清楚。最近的发现:最近的研究表明,代谢循环可以引起免疫细胞及其祖细胞的重编程。体重、LDL-C或葡萄糖循环诱导骨髓生成、单核细胞增多和/或免疫细胞功能改变。这导致免疫反应增强,最终使动脉粥样硬化恶化。摘要:尽管在临床和基础研究中代谢循环的测量方法存在差异,但结论是一致的:代谢循环会增加心血管疾病的严重程度。一些研究强调了骨髓细胞及其祖细胞重编程在代谢循环引起的动脉粥样硬化进展中的作用,但需要进一步的研究来更好地了解其背后的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cycling of metabolic states and metabolites as drivers of atherosclerosis.

Purpose of review: Cardiovascular diseases (CVDs) are a leading cause of death worldwide. While it is well known that obesity, dyslipidemia and diabetes are major risk factors of CVD, observational clinical studies have shown that variability in body weight, circulating LDL-cholesterol (LDL-C) or glucose levels further increase this risk. The underlying mechanisms, however, leading to increased risk of CVD due to metabolic cycling are not well understood.

Recent findings: Recent studies have shown that metabolic cycling can cause reprogramming of immune cells and their progenitors. Weight, LDL-C, or glucose cycling induced myelopoiesis, monocytosis and/or altered immune cell functions. This resulted in a heightened immune response, ultimately worsening atherosclerosis.

Summary: Even though there are differences in how metabolic cycling is measured in clinical and basic research studies, the conclusion remains the same: metabolic cycling increases CVD severity. Some studies have highlighted the role of reprogramming of myeloid cells and their progenitors in progression of atherosclerosis due to metabolic cycling, but further research is required to better understand the mechanisms behind it.

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来源期刊
Current opinion in lipidology
Current opinion in lipidology 医学-内分泌学与代谢
CiteScore
6.70
自引率
4.50%
发文量
64
审稿时长
6-12 weeks
期刊介绍: With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.
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