Bioactivity of pyridine and isoquinoline homodimers

This study reports the design and synthesis of homodimers incorporating pyridine and isoquinoline units at their termini, referred to as pyridine and isoquinoline homodimers. First, a pyridine homodimer was synthesized in moderate yield using a previously reported pyridin-4-yl counterpart. In contrast, the isoquinoline homodimer—containing two ether linkages and a methylene linker—was obtained in moderate to high yields. The resulting pyridine and isoquinoline homodimers exhibited antibacterial and antiviral activities. Thus, we successfully synthesized pyridine and isoquinoline homodimers 3 and 6 in moderate to high yields and demonstrated their antibacterial or antiviral properties by evaluating their bioactivities.