儿童耐药肺炎支原体。

IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Caeleigh Smith, Karin Ng, Kendra Sih, Alastair Mcalpine, Ran D Goldman
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引用次数: 0

摘要

问:我们诊所有一名5岁儿童,其临床表现与社区获得性肺炎相符。给她开了一个疗程的阿莫西林和阿奇霉素,但仍有发热,3天后返回诊所。这家人刚从日本旅行回来。目前治疗耐大环内酯肺炎支原体肺炎的现有证据是什么?答:耐大环内酯肺炎支原体(MRMP)在世界范围内的发病率正在上升,在中国、日本和台湾的患病率尤其高。大多数儿童证据支持使用四环素类药物治疗MRMP,支持氟喹诺酮类药物治疗这一适应症的证据较少。患有肺炎支原体肺炎的儿童和近期有高耐药率国家旅行史或在大环内酯治疗48至72小时内未得到改善的儿童应每日口服两次多西环素2mg /kg(每次剂量最大100mg)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resistant Mycoplasma pneumoniae in children.

Question: A 5-year-old child was seen in our clinic with a clinical presentation consistent with community-acquired pneumonia. She was prescribed a course of amoxicillin and azithromycin, but remained febrile and returned to the clinic 3 days later. The family just returned from a trip to Japan. What is the current available evidence for treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia?

Answer: Macrolide-resistant M pneumoniae (MRMP) rates are increasing worldwide, with especially high prevalence in China, Japan, and Taiwan. Most evidence in children supports the use of tetracyclines for MRMP with more limited evidence supporting fluoroquinolones for this indication. Children with M pneumoniae pneumonia and a history of recent travel to countries with high rates of resistance or who do not improve within 48 to 72 hours of macrolide treatment should be treated with 2 mg/kg of doxycycline orally twice daily (maximum 100 mg per dose).

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来源期刊
Canadian Family Physician
Canadian Family Physician 医学-医学:内科
CiteScore
2.30
自引率
9.70%
发文量
262
审稿时长
4-8 weeks
期刊介绍: Mission: Canadian Family Physician (CFP), a peer-reviewed medical journal, is the official publication of the College of Family Physicians of Canada. Our mission is to ensure that practitioners, researchers, educators and policy makers are informed on current issues and in touch with the latest thinking in the discipline of family medicine; to serve family physicians in all types of practice in every part of Canada in both official languages; to advance the continuing development of family medicine as a discipline; and to contribute to the ongoing improvement of patient care.
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