{"title":"慢性多关节痛1例18F-FDG和68Ga-FAPI PET/CT分子影像学表现。","authors":"Aparna Mahalik, Sivasankar Kanankulam Velliangiri, Sanjana Ballal, Rakesh Kumar","doi":"10.4103/ijnm.ijnm_152_23","DOIUrl":null,"url":null,"abstract":"<p><p>Positron emission tomography (PET) with <sup>18</sup>F-fluorodeoxyglucose for detection of active inflammation is well documented; however, the <i>in vivo</i> visualization of immune-mediated tissue remodeling has not been possible till date. With the recent development of <sup>68</sup>Ga-fibroblast activation protein inhibitors (FAPI), which specifically binds to the activated fibroblasts located around the synovium allowing for the visualization of mesenchymal and stromal activation process <i>in vivo</i>, it is possible to use this modality to use as an objective indicator of disease activity. We observed increased FAPI uptake around all the large joints of the bilateral upper and lower limbs of a chronic polyarthralgia patient. In view of the specificity of FAPI for the activated fibroblasts, the possibility of future therapeutic approach using FAPI must, therefore, be kept in mind.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 2","pages":"113-114"},"PeriodicalIF":0.5000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303212/pdf/","citationCount":"0","resultStr":"{\"title\":\"Molecular imaging findings with <sup>18</sup>F-FDG and <sup>68</sup>Ga-FAPI PET/CT in a case of chronic polyarthralgia.\",\"authors\":\"Aparna Mahalik, Sivasankar Kanankulam Velliangiri, Sanjana Ballal, Rakesh Kumar\",\"doi\":\"10.4103/ijnm.ijnm_152_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Positron emission tomography (PET) with <sup>18</sup>F-fluorodeoxyglucose for detection of active inflammation is well documented; however, the <i>in vivo</i> visualization of immune-mediated tissue remodeling has not been possible till date. With the recent development of <sup>68</sup>Ga-fibroblast activation protein inhibitors (FAPI), which specifically binds to the activated fibroblasts located around the synovium allowing for the visualization of mesenchymal and stromal activation process <i>in vivo</i>, it is possible to use this modality to use as an objective indicator of disease activity. We observed increased FAPI uptake around all the large joints of the bilateral upper and lower limbs of a chronic polyarthralgia patient. In view of the specificity of FAPI for the activated fibroblasts, the possibility of future therapeutic approach using FAPI must, therefore, be kept in mind.</p>\",\"PeriodicalId\":45830,\"journal\":{\"name\":\"Indian Journal of Nuclear Medicine\",\"volume\":\"40 2\",\"pages\":\"113-114\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303212/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Nuclear Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ijnm.ijnm_152_23\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Nuclear Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijnm.ijnm_152_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/27 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Molecular imaging findings with 18F-FDG and 68Ga-FAPI PET/CT in a case of chronic polyarthralgia.
Positron emission tomography (PET) with 18F-fluorodeoxyglucose for detection of active inflammation is well documented; however, the in vivo visualization of immune-mediated tissue remodeling has not been possible till date. With the recent development of 68Ga-fibroblast activation protein inhibitors (FAPI), which specifically binds to the activated fibroblasts located around the synovium allowing for the visualization of mesenchymal and stromal activation process in vivo, it is possible to use this modality to use as an objective indicator of disease activity. We observed increased FAPI uptake around all the large joints of the bilateral upper and lower limbs of a chronic polyarthralgia patient. In view of the specificity of FAPI for the activated fibroblasts, the possibility of future therapeutic approach using FAPI must, therefore, be kept in mind.
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