{"title":"复发性肉芽肿性阿米巴脑炎。","authors":"Sampurna Chowdhury, Yamini Priyanka, Ayush Agarwal, Divyani Garg, Ajay Garg, Hemlata Jangir, Achal K Srivastava","doi":"10.1136/pn-2025-004674","DOIUrl":null,"url":null,"abstract":"<p><p>Free-living amoebae like <i>Naegleria fowleri</i>, <i>Acanthamoeba</i> or <i>Balamuthia mandrillaris</i> are rare causes of central nervous system infections. <i>Naegleria fowleri</i> causes primary amoebic meningoencephalitis, whereas the latter two cause granulomatous amoebic encephalitis, which usually occurs in immunocompromised people and is almost universal fatal despite treatment. Early diagnosis is challenging due to the non-specific neurological symptoms, and there are no specific treatment guidelines. We report a case of successfully treated relapsing <i>Acanthamoeba</i> encephalitis in an immunocompetent individual.</p>","PeriodicalId":39343,"journal":{"name":"PRACTICAL NEUROLOGY","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Relapsing granulomatous amoebic encephalitis.\",\"authors\":\"Sampurna Chowdhury, Yamini Priyanka, Ayush Agarwal, Divyani Garg, Ajay Garg, Hemlata Jangir, Achal K Srivastava\",\"doi\":\"10.1136/pn-2025-004674\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Free-living amoebae like <i>Naegleria fowleri</i>, <i>Acanthamoeba</i> or <i>Balamuthia mandrillaris</i> are rare causes of central nervous system infections. <i>Naegleria fowleri</i> causes primary amoebic meningoencephalitis, whereas the latter two cause granulomatous amoebic encephalitis, which usually occurs in immunocompromised people and is almost universal fatal despite treatment. Early diagnosis is challenging due to the non-specific neurological symptoms, and there are no specific treatment guidelines. We report a case of successfully treated relapsing <i>Acanthamoeba</i> encephalitis in an immunocompetent individual.</p>\",\"PeriodicalId\":39343,\"journal\":{\"name\":\"PRACTICAL NEUROLOGY\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-07-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"PRACTICAL NEUROLOGY\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1136/pn-2025-004674\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"PRACTICAL NEUROLOGY","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/pn-2025-004674","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Free-living amoebae like Naegleria fowleri, Acanthamoeba or Balamuthia mandrillaris are rare causes of central nervous system infections. Naegleria fowleri causes primary amoebic meningoencephalitis, whereas the latter two cause granulomatous amoebic encephalitis, which usually occurs in immunocompromised people and is almost universal fatal despite treatment. Early diagnosis is challenging due to the non-specific neurological symptoms, and there are no specific treatment guidelines. We report a case of successfully treated relapsing Acanthamoeba encephalitis in an immunocompetent individual.
期刊介绍:
The essential point of Practical Neurology is that it is practical in the sense of being useful for everyone who sees neurological patients and who wants to keep up to date, and safe, in managing them. In other words this is a journal for jobbing neurologists - which most of us are for at least part of our time - who plough through the tension headaches and funny turns week in and week out. Primary research literature potentially relevant to routine clinical practice is far too much for any neurologist to read, let alone understand, critically appraise and assimilate. Therefore, if research is to influence clinical practice appropriately and quickly it has to be digested and provided to neurologists in an informative and convenient way.