Prospective, randomized study on the effects of autologous concentrated growth factors in the treatment of cystic lesions of the jaw.

Objective: The aim of the study was to investigate the efficacy of autologous concentrated growth factors (aCGF) in the treatment and healing of cystic lesions of the jaw.

Material and methods: In this prospective randomized intervention study 138 patients were enrolled, with 68 patients undergoing cystectomy alone and 70 patients undergoing cystectomy with defect filling using autologous concentrated growth factors. Bone healing was volumetrically measured using cone beam computed tomography (CBCT) at 6 and 12 months postoperatively. Clinical follow-ups were conducted 14 days, 1 month, 3 months, 6 months, and 12 months after the treatment.

Results: In both groups, almost complete bone healing occurred, with no significant differences observed between the two groups (P =0.484). In the aCGF group there was a trend towards a reduction in wound healing disturbances after 14 days, although this reduction was not statistically significant (P =0.071).

Conclusion: The use of aCGF following cystectomy does not show radiologically measurable significantly improved bone healing; however, a tendency towards improved wound healing compared to cystectomy without any filling materials could be observed in the initial healing period.