Arum Choi, Dayeon Bak, Jimin Kim, Se Won Oh, Yoonho Nam, Hyun Gi Kim
{"title":"新生儿脑缺氧缺血性损伤与mri衍生淋巴功能参数的关系。","authors":"Arum Choi, Dayeon Bak, Jimin Kim, Se Won Oh, Yoonho Nam, Hyun Gi Kim","doi":"10.3348/kjr.2025.0300","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association between hypoxic-ischemic injury (HII) of the brain and glymphatic function using MRI-derived parameters in neonates.</p><p><strong>Materials and methods: </strong>This retrospective, single-institution study collected brain MRI scans of 127 neonates between July 2020 and July 2022. The volume and fraction of the basal ganglia perivascular space (BG-PVS) were automatically extracted using three-dimensional T2-weighted image processing. Diffusion-tensor imaging (DTI) along the PVS (DTI-ALPS) index values were derived from the DTI maps. BG-PVS and DTI-ALPS parameters were compared between neonates with and without HII. The correlations between MRI-derived glymphatic parameters and corrected gestational age (CGA), as well as between BG-PVS measurements and the DTI-ALPS index, were analyzed using Spearman coefficients. Multivariable logistic regression adjusted for age, sex, birth weight, and mode of delivery was performed to examine the associations between each glymphatic parameter and HII.</p><p><strong>Results: </strong>This study included 97 neonates without HII (median gestational age [GA]: 252 days) and 30 with HII (median GA: 252 days). Neonates with HII had smaller BG-PVS volumes (19 mm³ vs. 33 mm³, <i>P</i> = 0.001) and fractions (0.29% vs. 0.54%, <i>P</i> = 0.003) compared to neonates without HII. The DTI-ALPS index values did not differ significantly between neonates with and without HII (<i>P</i> = 0.54). CGA correlated negatively with BG-PVS measurements (ρ = -0.21 to -0.26, all <i>P</i> < 0.05) and positively with DTI-ALPS index values (ρ = 0.22, <i>P</i> = 0.014). BG-PVS measurements and DTI-ALPS index values were not significantly correlated (ρ = -0.28 to -0.08, all <i>P</i> > 0.05). Multivariable logistic regression revealed a negative association between BG-PVS volume (odds ratio [OR]: 0.96 per mm³ increase, 95% confidence interval [CI]: 0.93-0.99) and fraction (OR: 0.15 per % increase, 95% CI: 0.03-0.79) with HII, while DTI-ALPS index values were not significantly associated with HII (OR: 0.10, 95% CI: 0.00-25.41).</p><p><strong>Conclusion: </strong>Neonates with HII demonstrated smaller BG-PVS volume and fraction compared with those without HII, indicating potential alterations in glymphatic function among affected newborns.</p>","PeriodicalId":17881,"journal":{"name":"Korean Journal of Radiology","volume":"26 8","pages":"782-792"},"PeriodicalIF":5.3000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318655/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of Hypoxic-Ischemic Injury of the Brain With MRI-Derived Glymphatic Function Parameters in Neonates.\",\"authors\":\"Arum Choi, Dayeon Bak, Jimin Kim, Se Won Oh, Yoonho Nam, Hyun Gi Kim\",\"doi\":\"10.3348/kjr.2025.0300\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate the association between hypoxic-ischemic injury (HII) of the brain and glymphatic function using MRI-derived parameters in neonates.</p><p><strong>Materials and methods: </strong>This retrospective, single-institution study collected brain MRI scans of 127 neonates between July 2020 and July 2022. The volume and fraction of the basal ganglia perivascular space (BG-PVS) were automatically extracted using three-dimensional T2-weighted image processing. Diffusion-tensor imaging (DTI) along the PVS (DTI-ALPS) index values were derived from the DTI maps. BG-PVS and DTI-ALPS parameters were compared between neonates with and without HII. The correlations between MRI-derived glymphatic parameters and corrected gestational age (CGA), as well as between BG-PVS measurements and the DTI-ALPS index, were analyzed using Spearman coefficients. Multivariable logistic regression adjusted for age, sex, birth weight, and mode of delivery was performed to examine the associations between each glymphatic parameter and HII.</p><p><strong>Results: </strong>This study included 97 neonates without HII (median gestational age [GA]: 252 days) and 30 with HII (median GA: 252 days). Neonates with HII had smaller BG-PVS volumes (19 mm³ vs. 33 mm³, <i>P</i> = 0.001) and fractions (0.29% vs. 0.54%, <i>P</i> = 0.003) compared to neonates without HII. The DTI-ALPS index values did not differ significantly between neonates with and without HII (<i>P</i> = 0.54). CGA correlated negatively with BG-PVS measurements (ρ = -0.21 to -0.26, all <i>P</i> < 0.05) and positively with DTI-ALPS index values (ρ = 0.22, <i>P</i> = 0.014). BG-PVS measurements and DTI-ALPS index values were not significantly correlated (ρ = -0.28 to -0.08, all <i>P</i> > 0.05). Multivariable logistic regression revealed a negative association between BG-PVS volume (odds ratio [OR]: 0.96 per mm³ increase, 95% confidence interval [CI]: 0.93-0.99) and fraction (OR: 0.15 per % increase, 95% CI: 0.03-0.79) with HII, while DTI-ALPS index values were not significantly associated with HII (OR: 0.10, 95% CI: 0.00-25.41).</p><p><strong>Conclusion: </strong>Neonates with HII demonstrated smaller BG-PVS volume and fraction compared with those without HII, indicating potential alterations in glymphatic function among affected newborns.</p>\",\"PeriodicalId\":17881,\"journal\":{\"name\":\"Korean Journal of Radiology\",\"volume\":\"26 8\",\"pages\":\"782-792\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12318655/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Korean Journal of Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3348/kjr.2025.0300\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Korean Journal of Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3348/kjr.2025.0300","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Association of Hypoxic-Ischemic Injury of the Brain With MRI-Derived Glymphatic Function Parameters in Neonates.
Objective: To evaluate the association between hypoxic-ischemic injury (HII) of the brain and glymphatic function using MRI-derived parameters in neonates.
Materials and methods: This retrospective, single-institution study collected brain MRI scans of 127 neonates between July 2020 and July 2022. The volume and fraction of the basal ganglia perivascular space (BG-PVS) were automatically extracted using three-dimensional T2-weighted image processing. Diffusion-tensor imaging (DTI) along the PVS (DTI-ALPS) index values were derived from the DTI maps. BG-PVS and DTI-ALPS parameters were compared between neonates with and without HII. The correlations between MRI-derived glymphatic parameters and corrected gestational age (CGA), as well as between BG-PVS measurements and the DTI-ALPS index, were analyzed using Spearman coefficients. Multivariable logistic regression adjusted for age, sex, birth weight, and mode of delivery was performed to examine the associations between each glymphatic parameter and HII.
Results: This study included 97 neonates without HII (median gestational age [GA]: 252 days) and 30 with HII (median GA: 252 days). Neonates with HII had smaller BG-PVS volumes (19 mm³ vs. 33 mm³, P = 0.001) and fractions (0.29% vs. 0.54%, P = 0.003) compared to neonates without HII. The DTI-ALPS index values did not differ significantly between neonates with and without HII (P = 0.54). CGA correlated negatively with BG-PVS measurements (ρ = -0.21 to -0.26, all P < 0.05) and positively with DTI-ALPS index values (ρ = 0.22, P = 0.014). BG-PVS measurements and DTI-ALPS index values were not significantly correlated (ρ = -0.28 to -0.08, all P > 0.05). Multivariable logistic regression revealed a negative association between BG-PVS volume (odds ratio [OR]: 0.96 per mm³ increase, 95% confidence interval [CI]: 0.93-0.99) and fraction (OR: 0.15 per % increase, 95% CI: 0.03-0.79) with HII, while DTI-ALPS index values were not significantly associated with HII (OR: 0.10, 95% CI: 0.00-25.41).
Conclusion: Neonates with HII demonstrated smaller BG-PVS volume and fraction compared with those without HII, indicating potential alterations in glymphatic function among affected newborns.
期刊介绍：
The inaugural issue of the Korean J Radiol came out in March 2000. Our journal aims to produce and propagate knowledge on radiologic imaging and related sciences.
A unique feature of the articles published in the Journal will be their reflection of global trends in radiology combined with an East-Asian perspective. Geographic differences in disease prevalence will be reflected in the contents of papers, and this will serve to enrich our body of knowledge.
World''s outstanding radiologists from many countries are serving as editorial board of our journal.
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