纳米共晶作为纳米技术调节难溶性药物溶解度和生物利用度的方法。

IF 3.3 4区 医学 Q3 CHEMISTRY, MEDICINAL
Deepak Tomar, Mainuddin, Anshika, Amulya Jindal
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引用次数: 0

摘要

各种药物都面临溶解度参数的限制,这限制了它们的总口服生物利用度,这类药物也属于生物药品分类系统(BCS)第二类。为了克服这些限制,人们设计了各种新型药物递送系统(DDS),包括脂质体、乳质体、纳米结构脂质载体(nlc)、纳米乳、自纳米乳化DDS (SNEDDS)等,但最有效和最容易制备的DDS是纳米共晶(NCs)。本研究的目的是明确强调NCs,他们的发展和各种优势,有关他们的使用作为DDS。NCs的开发是为了改变动态药物调整的特性,与原始形式相比,具有增强的溶解性、崩解性和生物利用度。由于它们的高表面体积比和共晶结构,易于在纳米尺度范围内转换,可以进一步提高这些品质。尽管NC已经成为许多研究的主题,但药物NC研究仍处于早期阶段。在这篇综述中,讨论了许多组织nc的方法。通过对一些科学方法和表述的全面考察,将提供对nc的详细理解。本分析的目的是为具有制药工业经济价值的新型nc的开发提供方向,并被证明是提高药物水溶性的有效方法,并最终导致药物的口服总生物利用度的调节。从未来的角度来看,NCs由于其易于开发和更好的理化性质,将成为现代DDS。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nano-cocrystals as Nanotechnology-based Approach to Modulate Solubility and Bioavailability of Poorly Soluble Drugs.

Various drugs face limitations in their solubility parameters which limits their total oral bioavailability, and such drugs are also categorized under the biopharmaceutical classification system (BCS) Class II. To modulate such limitations there were various novel drug delivery systems (DDS) designed including lipid-based DDS such as liposomes, niosomes, nanostructured lipid carriers (NLCs), nanoemulsion, self-nanoemulsifying DDS (SNEDDS) but the most effective and easily prepared DDS is nano-cocrystals (NCs). This study aims to give a clear emphasis on the NCs, their development and various advantages related to their usage as DDS. NCs are developed to modify the characteristics of dynamic drug adjustments with enhanced dissolvability, disintegration, and bioavailability compared to their naive form. Due to their high surface-to-volume ratio and co-crystal structure, easily converted in the nanosized range, they can further enhance these qualities. Even though NCs have been the subject of numerous studies, drug NC research is still in its early stages. In this review, many methods for organizing NCs have been discussed. A detailed understanding of NCs will be provided by a thorough examination of a few scientific methods and representations. The purpose of this analysis is to provide direction for the development of novel NCs with pharmaceutical industry economic value and proven as an effective approach for enhancement of drug aqueous solubility and ultimately resulted in the modulation of total oral bioavailability of the drug. NCs will be the modern DDS from the futuristic point of view due to their easy development and better physiochemical properties.

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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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