Nemencio Nicodemus, Virgilio Novero, Wiryawan Permadi, Ketut Suastika, Alexander Tan Tong Boon, Chaicharn Deerochanawong, Kerstin Brand, Maria Christina Hanindita, Alina Markova
{"title":"二甲双胍治疗妊娠期和围孕期高血糖:来自亚太地区7个国家/州的专家建议","authors":"Nemencio Nicodemus, Virgilio Novero, Wiryawan Permadi, Ketut Suastika, Alexander Tan Tong Boon, Chaicharn Deerochanawong, Kerstin Brand, Maria Christina Hanindita, Alina Markova","doi":"10.1080/03007995.2025.2496430","DOIUrl":null,"url":null,"abstract":"<p><p>Hyperglycemia in pregnancy (HIP) poses significant risks to maternal and fetal health yet remains underreported, particularly in the Asia-Pacific region. This public health challenge includes gestational diabetes mellitus, pre-existing diabetes, and diabetes diagnosed during pregnancy, with regional prevalence rates as high as 28%. Left untreated, HIP can lead to adverse maternal outcomes such as preeclampsia and excessive gestational weight gain, as well as neonatal complications, including macrosomia and neonatal hypoglycemia. International and regional guidelines emphasize early detection and tailored interventions when addressing unmet medical needs in HIP management. Screening protocols vary, with a one-step oral glucose tolerance test increasingly favored for its diagnostic accuracy. Metformin, recognized for its favorable safety profile, efficacy, and cost-effectiveness, has emerged as a preferred first-line treatment alongside lifestyle modifications. Recent updates to metformin's regulatory labeling highlight its safe use during pregnancy, with evidence demonstrating benefits such as reduced maternal weight gain and neonatal complications. This expert recommendation from the Asia-Pacific region focus on the use of metformin during pregnancy and the periconceptional period. Recommendations advocate for routine screening, optimal glycemic control, and structured postpartum care to mitigate HIP's long-term health impacts. Integrating metformin into management strategies enhances patient satisfaction, accessibility, and overall outcomes, offering a practical solution to improve maternal and neonatal health in diverse healthcare settings.</p>","PeriodicalId":10814,"journal":{"name":"Current Medical Research and Opinion","volume":" ","pages":"1185-1196"},"PeriodicalIF":2.2000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Metformin in the treatment of hyperglycemia during pregnancy and periconception: guideline-informed expert recommendations from seven countries/states in the Asia-Pacific region.\",\"authors\":\"Nemencio Nicodemus, Virgilio Novero, Wiryawan Permadi, Ketut Suastika, Alexander Tan Tong Boon, Chaicharn Deerochanawong, Kerstin Brand, Maria Christina Hanindita, Alina Markova\",\"doi\":\"10.1080/03007995.2025.2496430\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Hyperglycemia in pregnancy (HIP) poses significant risks to maternal and fetal health yet remains underreported, particularly in the Asia-Pacific region. This public health challenge includes gestational diabetes mellitus, pre-existing diabetes, and diabetes diagnosed during pregnancy, with regional prevalence rates as high as 28%. Left untreated, HIP can lead to adverse maternal outcomes such as preeclampsia and excessive gestational weight gain, as well as neonatal complications, including macrosomia and neonatal hypoglycemia. International and regional guidelines emphasize early detection and tailored interventions when addressing unmet medical needs in HIP management. Screening protocols vary, with a one-step oral glucose tolerance test increasingly favored for its diagnostic accuracy. Metformin, recognized for its favorable safety profile, efficacy, and cost-effectiveness, has emerged as a preferred first-line treatment alongside lifestyle modifications. Recent updates to metformin's regulatory labeling highlight its safe use during pregnancy, with evidence demonstrating benefits such as reduced maternal weight gain and neonatal complications. This expert recommendation from the Asia-Pacific region focus on the use of metformin during pregnancy and the periconceptional period. Recommendations advocate for routine screening, optimal glycemic control, and structured postpartum care to mitigate HIP's long-term health impacts. Integrating metformin into management strategies enhances patient satisfaction, accessibility, and overall outcomes, offering a practical solution to improve maternal and neonatal health in diverse healthcare settings.</p>\",\"PeriodicalId\":10814,\"journal\":{\"name\":\"Current Medical Research and Opinion\",\"volume\":\" \",\"pages\":\"1185-1196\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Medical Research and Opinion\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/03007995.2025.2496430\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/8/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Medical Research and Opinion","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/03007995.2025.2496430","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/1 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Metformin in the treatment of hyperglycemia during pregnancy and periconception: guideline-informed expert recommendations from seven countries/states in the Asia-Pacific region.
Hyperglycemia in pregnancy (HIP) poses significant risks to maternal and fetal health yet remains underreported, particularly in the Asia-Pacific region. This public health challenge includes gestational diabetes mellitus, pre-existing diabetes, and diabetes diagnosed during pregnancy, with regional prevalence rates as high as 28%. Left untreated, HIP can lead to adverse maternal outcomes such as preeclampsia and excessive gestational weight gain, as well as neonatal complications, including macrosomia and neonatal hypoglycemia. International and regional guidelines emphasize early detection and tailored interventions when addressing unmet medical needs in HIP management. Screening protocols vary, with a one-step oral glucose tolerance test increasingly favored for its diagnostic accuracy. Metformin, recognized for its favorable safety profile, efficacy, and cost-effectiveness, has emerged as a preferred first-line treatment alongside lifestyle modifications. Recent updates to metformin's regulatory labeling highlight its safe use during pregnancy, with evidence demonstrating benefits such as reduced maternal weight gain and neonatal complications. This expert recommendation from the Asia-Pacific region focus on the use of metformin during pregnancy and the periconceptional period. Recommendations advocate for routine screening, optimal glycemic control, and structured postpartum care to mitigate HIP's long-term health impacts. Integrating metformin into management strategies enhances patient satisfaction, accessibility, and overall outcomes, offering a practical solution to improve maternal and neonatal health in diverse healthcare settings.
期刊介绍:
Current Medical Research and Opinion is a MEDLINE-indexed, peer-reviewed, international journal for the rapid publication of original research on new and existing drugs and therapies, Phase II-IV studies, and post-marketing investigations. Equivalence, safety and efficacy/effectiveness studies are especially encouraged. Preclinical, Phase I, pharmacoeconomic, outcomes and quality of life studies may also be considered if there is clear clinical relevance