{"title":"一种新的白桑猴样病毒的全基因组分析。","authors":"Hanze Zheng, Yangwei Gao, Xiaodi Hu, Zhongtian Xu, Jian-Ping Chen, Yiyuan Li","doi":"10.1007/s00705-025-06378-3","DOIUrl":null,"url":null,"abstract":"<div><p>Mulberries (genus <i>Morus</i>) are important to sericulture. Due to interspecific hybridization and the existence of various cultivars, the virome of many <i>Morus</i> species is still unknown. In this study, we identified a novel negative-sense phenui-like virus in <i>Morus alba</i> and determined its genome sequence. The virus possesses three linear single-stranded negative-sense RNA segments: RNA1 (7,329 nt), RNA2 (1,276 nt), and RNA3 (1,222 nt). Each of the three segments contains an open reading frame (ORF), encoding the RNA-dependent RNA polymerase (RdRP), the movement protein (MP), and the nucleocapsid protein (N), respectively. Phylogenetic analysis placed this virus within a clade including members of the genus <i>Rubodvirus</i> (family <i>Phenuiviridae</i>, order <i>Hareavirales</i>, class <i>Bunyaviricetes</i>) with raspberry rubodvirus 1, grapevine Muscat rose virus, and apple rubbery wood virus 2 being the closest relatives. Small interfering RNA (siRNA) sequencing data suggested that the virus replicates in <i>Morus alba</i>. Our study provides the first report of a rubodvirus in <i>Morus alba</i>.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 8","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Complete genome analysis of a novel phenui-like virus in Morus alba\",\"authors\":\"Hanze Zheng, Yangwei Gao, Xiaodi Hu, Zhongtian Xu, Jian-Ping Chen, Yiyuan Li\",\"doi\":\"10.1007/s00705-025-06378-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Mulberries (genus <i>Morus</i>) are important to sericulture. Due to interspecific hybridization and the existence of various cultivars, the virome of many <i>Morus</i> species is still unknown. In this study, we identified a novel negative-sense phenui-like virus in <i>Morus alba</i> and determined its genome sequence. The virus possesses three linear single-stranded negative-sense RNA segments: RNA1 (7,329 nt), RNA2 (1,276 nt), and RNA3 (1,222 nt). Each of the three segments contains an open reading frame (ORF), encoding the RNA-dependent RNA polymerase (RdRP), the movement protein (MP), and the nucleocapsid protein (N), respectively. Phylogenetic analysis placed this virus within a clade including members of the genus <i>Rubodvirus</i> (family <i>Phenuiviridae</i>, order <i>Hareavirales</i>, class <i>Bunyaviricetes</i>) with raspberry rubodvirus 1, grapevine Muscat rose virus, and apple rubbery wood virus 2 being the closest relatives. Small interfering RNA (siRNA) sequencing data suggested that the virus replicates in <i>Morus alba</i>. Our study provides the first report of a rubodvirus in <i>Morus alba</i>.</p></div>\",\"PeriodicalId\":8359,\"journal\":{\"name\":\"Archives of Virology\",\"volume\":\"170 8\",\"pages\":\"\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-07-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Virology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00705-025-06378-3\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Virology","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s00705-025-06378-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VIROLOGY","Score":null,"Total":0}
Complete genome analysis of a novel phenui-like virus in Morus alba
Mulberries (genus Morus) are important to sericulture. Due to interspecific hybridization and the existence of various cultivars, the virome of many Morus species is still unknown. In this study, we identified a novel negative-sense phenui-like virus in Morus alba and determined its genome sequence. The virus possesses three linear single-stranded negative-sense RNA segments: RNA1 (7,329 nt), RNA2 (1,276 nt), and RNA3 (1,222 nt). Each of the three segments contains an open reading frame (ORF), encoding the RNA-dependent RNA polymerase (RdRP), the movement protein (MP), and the nucleocapsid protein (N), respectively. Phylogenetic analysis placed this virus within a clade including members of the genus Rubodvirus (family Phenuiviridae, order Hareavirales, class Bunyaviricetes) with raspberry rubodvirus 1, grapevine Muscat rose virus, and apple rubbery wood virus 2 being the closest relatives. Small interfering RNA (siRNA) sequencing data suggested that the virus replicates in Morus alba. Our study provides the first report of a rubodvirus in Morus alba.
期刊介绍：
Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.
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