{"title":"超声导丝血管消融中的空化-振动耦合机理。","authors":"Guang Yao, Maozhong Wu, Jianhua Lai, Youcheng Lv, Lijuan Zheng, Chengyong Wang","doi":"10.1016/j.ultsonch.2025.107474","DOIUrl":null,"url":null,"abstract":"<p><p>Effective treatment of diverse vascular occlusions requires precise energy delivery and tissue-specific ablation strategies. This study systematically investigates the coupled mechanical vibration and cavitation mechanisms of a novel flexible ultrasonic guidewire during ablation of calcified, lipid-rich, and thrombotic occlusion mimics. Integrating numerical simulations and experimental validation, this work elucidates the dynamic interplay between ultrasonic parameters and tissue-specific ablation outcomes. For calcified mimics, mechanical vibrational impact is the dominant ablation mechanism, achieving substantial material removal primarily through fracture. Lipid-rich tissue ablation is driven by emulsification via cavitation microjets and acoustic streaming, generating microparticles with sizes of 10-250 μm, controllable by ultrasonic power. Thrombus ablation involves initial penetration followed by erythrocyte lysis, primarily mediated by transient cavitation. Crucially, guidewire bending significantly attenuates tip vibration amplitude, resulting in a reduction of 14.3-30.9 %, with titanium alloy exhibiting superior energy transmission stability under curvature compared to nickel-titanium. These findings highlight distinct, tissue-dependent ablation paradigms: mechanical fragmentation for hard tissues compared to cavitation and streaming induced emulsification or lysis for soft tissues. This mechanistic understanding is foundational for designing adaptive ultrasonic guidewires capable of adjusting energy delivery modes based on real time feedback of tissue characteristics, thereby enhancing the precision and efficacy of endovascular interventions.</p>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":" ","pages":"107474"},"PeriodicalIF":9.7000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cavitation-vibration coupling mechanism in ultrasonic guidewire vascular ablation.\",\"authors\":\"Guang Yao, Maozhong Wu, Jianhua Lai, Youcheng Lv, Lijuan Zheng, Chengyong Wang\",\"doi\":\"10.1016/j.ultsonch.2025.107474\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Effective treatment of diverse vascular occlusions requires precise energy delivery and tissue-specific ablation strategies. This study systematically investigates the coupled mechanical vibration and cavitation mechanisms of a novel flexible ultrasonic guidewire during ablation of calcified, lipid-rich, and thrombotic occlusion mimics. Integrating numerical simulations and experimental validation, this work elucidates the dynamic interplay between ultrasonic parameters and tissue-specific ablation outcomes. For calcified mimics, mechanical vibrational impact is the dominant ablation mechanism, achieving substantial material removal primarily through fracture. Lipid-rich tissue ablation is driven by emulsification via cavitation microjets and acoustic streaming, generating microparticles with sizes of 10-250 μm, controllable by ultrasonic power. Thrombus ablation involves initial penetration followed by erythrocyte lysis, primarily mediated by transient cavitation. Crucially, guidewire bending significantly attenuates tip vibration amplitude, resulting in a reduction of 14.3-30.9 %, with titanium alloy exhibiting superior energy transmission stability under curvature compared to nickel-titanium. These findings highlight distinct, tissue-dependent ablation paradigms: mechanical fragmentation for hard tissues compared to cavitation and streaming induced emulsification or lysis for soft tissues. This mechanistic understanding is foundational for designing adaptive ultrasonic guidewires capable of adjusting energy delivery modes based on real time feedback of tissue characteristics, thereby enhancing the precision and efficacy of endovascular interventions.</p>\",\"PeriodicalId\":442,\"journal\":{\"name\":\"Ultrasonics Sonochemistry\",\"volume\":\" \",\"pages\":\"107474\"},\"PeriodicalIF\":9.7000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ultrasonics Sonochemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ultsonch.2025.107474\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"ACOUSTICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ultrasonics Sonochemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.ultsonch.2025.107474","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/24 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ACOUSTICS","Score":null,"Total":0}
Cavitation-vibration coupling mechanism in ultrasonic guidewire vascular ablation.
Effective treatment of diverse vascular occlusions requires precise energy delivery and tissue-specific ablation strategies. This study systematically investigates the coupled mechanical vibration and cavitation mechanisms of a novel flexible ultrasonic guidewire during ablation of calcified, lipid-rich, and thrombotic occlusion mimics. Integrating numerical simulations and experimental validation, this work elucidates the dynamic interplay between ultrasonic parameters and tissue-specific ablation outcomes. For calcified mimics, mechanical vibrational impact is the dominant ablation mechanism, achieving substantial material removal primarily through fracture. Lipid-rich tissue ablation is driven by emulsification via cavitation microjets and acoustic streaming, generating microparticles with sizes of 10-250 μm, controllable by ultrasonic power. Thrombus ablation involves initial penetration followed by erythrocyte lysis, primarily mediated by transient cavitation. Crucially, guidewire bending significantly attenuates tip vibration amplitude, resulting in a reduction of 14.3-30.9 %, with titanium alloy exhibiting superior energy transmission stability under curvature compared to nickel-titanium. These findings highlight distinct, tissue-dependent ablation paradigms: mechanical fragmentation for hard tissues compared to cavitation and streaming induced emulsification or lysis for soft tissues. This mechanistic understanding is foundational for designing adaptive ultrasonic guidewires capable of adjusting energy delivery modes based on real time feedback of tissue characteristics, thereby enhancing the precision and efficacy of endovascular interventions.
期刊介绍:
Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels.
Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.