自身免疫和骨髓纤维化之间的交叉路径：自身免疫骨髓纤维化的案例。

IF 8.3 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2025-07-28 DOI:10.1016/j.autrev.2025.103893

Francesco Carubbi , Alessia Alunno , Elisa Matone , Alessandro Lucchesi , Gerardo Musuraca , Claudio Ferri

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引用次数: 0

摘要

骨髓纤维化常见于血液系统恶性肿瘤患者，包括骨髓增生性肿瘤（mpn）。BMF最常见的原因是bcr - abl阴性的MPN原发性骨髓纤维化（PMF），然而，BMF也可能由各种非肿瘤性疾病如感染、内分泌疾病和自身免疫性疾病（ADs）引起。自身免疫性骨髓纤维化（AIMF）是一种与完全成熟的AD（继发性AIMF）或无明显AD（原发性AIMF）的自身免疫血清学体征相关的BMF。虽然已经发表了孤立的病例报告和病例系列，但AIMF仍然是一种认识不足的疾病。因此，我们对AIMF的发病机制、诊断和治疗进行了综述，并对相关文献进行了批判性评价，特别关注AIMF与PMF的异同。

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Intersecting paths between autoimmunity and bone marrow fibrosis: the case of autoimmune myelofibrosis.

Bone marrow fibrosis is frequently observed in patients with haematological malignancies including myeloproliferative neoplasm (MPNs). The most common cause of BMF is the BCR-ABL-negative MPN primary myelofibrosis (PMF) however, BMF may also be caused by a variety of non-neoplastic disorders such as infections, endocrine diseases and autoimmune diseases (ADs). Autoimmune myelofibrosis (AIMF) is a type of BMF associated with either a fully blown AD (secondary AIMF) or serological signs of autoimmunity without an overt AD (primary AIMF). Although isolated case reports and case series have been published, AIMF remains a poorly recognized disorder. Therefore, we performed a scoping review and critically appraised the literature on AIMF pathogenesis, diagnosis and treatment with a particular focus on similarities and differences between AIMF and PMF.

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来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.