8例精神分裂症遗传风险升高的神经典型个体诱导多能干细胞的产生

IF 0.7 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Stem cell research Pub Date : 2025-07-28 DOI:10.1016/j.scr.2025.103791

Sangho S. Myung , Srinidhi Rao Sripathy , Brady J. Maher

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引用次数: 0

摘要

精神分裂症（SCZ）是一种常见的使人衰弱的精神疾病，其特征是阳性和阴性症状，以及认知障碍。全基因组关联研究（GWAS）已经确定了数百个包含SCZ风险变异的基因组区域。对于每个个体，可以得出一个多基因风险评分（PRS），这是SCZ遗传易感性的一个指标。在这里，我们报道了从8个PRS升高的神经典型个体中产生的人类诱导多能干细胞（hiPSCs）。这些hiPSC系将有助于研究SCZ的常见变异风险，以及产生包含与SCZ风险相关的罕见变异的等基因系。

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Generation of induced pluripotent stem cells from 8 neurotypical individuals with elevated genetic risk for schizophrenia

Schizophrenia (SCZ) is a common and debilitating mental illness characterized by positive and negative symptoms, and impaired cognition. Genome-wide association studies (GWAS) have identified hundreds of genomic regions containing SCZ risk variants. For each individual, a polygenic risk score (PRS) can be derived, which is a metric of genetic susceptibility for SCZ. Here, we report the generation of human induced pluripotent stem cells (hiPSCs) from 8 neurotypical individuals with elevated PRS. These hiPSC lines will be useful to study common variant risk for SCZ and for the generation of isogenic lines containing rare variants associated with SCZ risk.

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来源期刊

Stem cell research 生物-生物工程与应用微生物

CiteScore

2.20

自引率

8.30%

发文量

338

审稿时长

55 days

期刊介绍： Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Submissions to Stem Cell Research, may cover all aspects of stem cells, including embryonic stem cells, tissue-specific stem cells, cancer stem cells, developmental studies, stem cell genomes, and translational research. Stem Cell Research publishes 6 issues a year.