苯胺的去芳构化-断裂-芳构化：与宽杂原子亲核试剂合成3,3-二取代吲哚的过程

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-07-30 DOI:10.1039/d5cc02309b

Priyankar Jha, Saddam Husen, Sagar Sinha, Ravindra Kumar

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引用次数: 0

摘要

在此，我们报道了一种催化氧化还原中性的方法，使用苯胺和异核试剂衍生的酮胺来实现氧吲哚的双官能化。该反应通过扩展共振稳定的四取代烯烃中间体进行脱芳-芳构化反应，有利于选择性生成具有宽化学空间的3,3-二取代吲哚，收率高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Dearomatization-Scission-Aromatization of Anilines: En route to Synthesis of 3,3-Disubstituted Oxindoles with Wide Heteroatom Nucleophiles

Herein, we report a catalytic, redox-neutral method for the difunctionalization of oxindoles using ketimines derived from anilines and heteronucleophiles. The reaction proceeds through dearomatization-aromatization strategy via tetra-substituted alkene intermediate stabilized by extended resonance, facilitating the selective formation of 3,3-disubstituted oxindoles with wide chemical space in good to high yields.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.