一种负载Pd纳米粒子的纳米级共价有机框架增强氢/光热协同治疗肿瘤

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-07-30 DOI:10.1039/d5cc03085d

Kai-Xuan Zhang, Meng-Yan Gao, Yan-Zheng Lu, Jin-Zhou Lv, Hao-Ran Wang, Yan-An Li, Yu-Bin Dong

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引用次数: 0

摘要

在此，我们报道了一种负载Pd纳米酶和H2的纳米级复合COF材料。获得的PdH2@COF已被证明通过破坏细胞内氧化还原平衡来影响线粒体功能，从而下调热休克蛋白（HSP）的表达，从而增强肿瘤的光热治疗。

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A Pd nanoparticle-loaded nanoscale covalent organic framework to enhance tumor therapy by synergistic hydrogen/photothermal therapy

Herein, we report a nanoscale composite COF material loaded with Pd nanoenzyme and H2 via a stepwise post-synthetic modification. The obtained PdH2@COF has been shown to affect mitochondrial function by disrupting the intracellular redox balance and thus down-regulated the expression of heat shock protein (HSP), thereby enhancing photothermal therapy of tumor.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.