空间和特征依赖的皮层回路模型中摄动响应的精确线性理论

IF 9.1 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Ho Yin Chau, Kenneth D. Miller, Agostina Palmigiano
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引用次数: 0

摘要

控制皮层网络对输入的反应以及这些反应从循环连接中出现的原则是什么?最近的实验通过测量小鼠初级视觉皮层对单细胞双光子光遗传扰动的反应来探讨这些问题。需要一个强有力的理论框架来确定这些反应对皮层复发的影响。在这里,我们提出了细胞类型特异性连通性对空间距离的依赖性的公式,该公式为具有多细胞类型和空间和特征依赖的连通性的模型的线性扰动响应提供了精确的解析解。重要的是,与以前的方法不同,该解决方案在强和弱皮质内耦合的情况下都是有效的。分析揭示了单细胞微扰响应的各种特征所隐含的连通性结构,例如令人惊讶的狭窄的附近激励空间半径,超过抑制占主导地位,平均激励和抑制之间的转换次数,以及这些响应对特征偏好的依赖性。将这些结果与现有的光遗传扰动数据进行比较,得出了对细胞类型特异性连接强度及其调谐依赖性的限制。最后,我们提供了关于抑制神经元对单细胞扰动的反应和神经元增益对扰动反应的调节的实验预测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exact linear theory of perturbation response in a space- and feature-dependent cortical circuit model
What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of single cells in the mouse primary visual cortex. A robust theoretical framework is needed to determine the implications of these responses for cortical recurrence. Here, we propose a formulation of the dependence of cell-type-specific connectivity on spatial distance that yields an exact analytic solution for the linear perturbation response of a model with multiple cell types and space- and feature-dependent connectivity. Importantly and unlike previous approaches, the solution is valid in regimes of strong as well as weak intracortical coupling. Analysis reveals the structure of connectivity implied by various features of single-cell perturbation responses, such as the surprisingly narrow spatial radius of nearby excitation beyond which inhibition dominates, the number of transitions between mean excitation and inhibition thereafter, and the dependence of these responses on feature preferences. Comparison of these results to existing optogenetic perturbation data yields constraints on cell-type-specific connection strengths and their tuning dependence. Finally, we provide experimental predictions regarding the response of inhibitory neurons to single-cell perturbations and the modulation of perturbation response by neuronal gain.
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来源期刊
CiteScore
19.00
自引率
0.90%
发文量
3575
审稿时长
2.5 months
期刊介绍: The Proceedings of the National Academy of Sciences (PNAS), a peer-reviewed journal of the National Academy of Sciences (NAS), serves as an authoritative source for high-impact, original research across the biological, physical, and social sciences. With a global scope, the journal welcomes submissions from researchers worldwide, making it an inclusive platform for advancing scientific knowledge.
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