强迫症患者纹状体功能梯度改变。

IF 4.8
Lachlan Webb, Luke Hearne, Ye E Tian, Andrew Zalesky, Conor Robinson, Caitlin V Hall, Saurabh Sonkusare, Bjorn Burgher, Michael Breakspear, Garance M Meyer, Andreas Horn, Sebastien Naze, Philip Mosley, Luca Cocchi
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引用次数: 0

摘要

背景:强迫症(OCD)与纹状体与大脑其他部分相互作用的功能改变有关。然而,对强迫症中这些变化的描述是不完整的。绘制功能性纹状体梯度为填补这一知识空白提供了新的机会。这些梯度提供了纹状体区域内全脑连通性连续变化的空间表征。因此,强迫症相关纹状体梯度的差异暗示纹状体连接的功能组织发生了变化。方法:我们计算了52名强迫症患者和45名对照组与全脑活动相关的空间纹状体梯度。梯度是在个体休息时和他们接受威胁-安全逆转任务时计算的。利用47名强迫症患者的纵向数据集,我们研究了纹状体梯度拓扑变化与症状严重程度波动之间的可能关联。结果:结果显示各组在静止状态下的主要梯度拓扑结构存在差异,特别是纹状体区域与壳核和尾状核重叠。随着时间的推移,表现出症状减轻的个体倾向于改变他们的梯度拓扑,以支持对照组参与者的平均拓扑。最后,与安全逆转(而非威胁逆转)评估相关的梯度显示,在右侧伏隔核和壳核之间的区域存在组间差异。结论:本研究提高了对强迫症纹状体连接谱的认识,支持纹状体拓扑结构的明显变化在症状表达中的核心作用。总的来说,这些结果鼓励了评估驱动纹状体拓扑动态重组的神经机制的研究,以及利用纹状体-皮层可塑性的治疗方法的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Altered striatal functional gradients in obsessive-compulsive disorder.

Background: Obsessive-compulsive disorder (OCD) is associated with functional alterations in how the striatum interacts with the rest of the brain. However, the characterization of these changes in OCD is incomplete. Mapping functional striatal gradients provides a new opportunity to fill this knowledge gap. These gradients provide a spatial representation of continuous changes in whole-brain connectivity within striatal regions. Thus, OCD-related differences in striatal gradients imply changes in the functional organisation of striatal connections.

Methods: We calculated spatial striatal gradients linked to whole brain activity in 52 people with OCD and 45 controls. Gradients were computed with individuals at rest and when they underwent a threat-safety reversal task. Using a longitudinal dataset of 47 people with OCD, we investigated possible associations between changes in striatal gradient topology and fluctuations in symptom severity.

Results: Results showed group differences in the main gradient topology at rest, specifically in striatal regions overlapping with the putamen and caudate. Individuals showing a reduction in symptoms over time tended to change their gradient topology in favour of the control participants' average topology. Finally, gradients linked to the appraisal of safety-reversal, but not threat-reversal, showed a group difference in a region separating the right nucleus accumbens and the putamen.

Conclusions: This study advances knowledge of striatal connectivity profiles in OCD, supporting a core role of distinct changes in striatal topology in the expression of symptoms. Collectively, these results encourage studies assessing neural mechanisms driving the dynamic reorganisation of striatal topology and the development of therapies leveraging striato-cortical plasticity.

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