自体外周静脉血在眼眶保存中的组织学和放射学评价:一项系统回顾和荟萃分析。

IF 1.8 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Frontiers in dental medicine Pub Date : 2025-07-11 eCollection Date: 2025-01-01 DOI:10.3389/fdmed.2025.1602738
Yusheng Meng, Min Wu, Shuang Wang, Xiuqiao Yang, Yun Liu
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引用次数: 0

摘要

目的:通过详细的荟萃分析和系统的研究,评估自体外周静脉血浓缩液(apvcs)保存眼窝的组织学和影像学疗效。设计:检索电子数据库至2025年1月31日。随机对照试验(RCTs)和对照临床试验(CCTs)的英文。拔牙后通过组织学和影像学评估牙槽骨重建情况。数据采用Revman5.3进行分析,偏倚风险采用Cochrane协作工具进行评估。结果:我们的meta分析共纳入了16项研究(12项随机对照试验和4项随机对照试验),涉及619个站点。结果表明,应用APVBCs可显著降低颊嵴垂直骨吸收(标准化平均差[SMD]: -0.30;95%置信区间[CI]: -0.54 ~ -0.06;p = 0.02, i2 = 5%)和腭/舌脊(SMD:-0.30, 95% CI: -0.54至-0.06;p = 0.02, i2 = 0%)。此外,使用APVBCs联合材料作为拔牙槽位填充材料,可以显著减少颊和腭/舌牙槽嵴的垂直吸收。新成骨百分比显示,在套窝保存期间APVBC的存在有统计学意义的增加(SMD: 1.27, 95% CI: 0.65-1.89;p I 2 = 71%)和APVBC +材料组(SMD: 0.85, 95% CI: 0.35-1.35;p = 0.0009, i2 = 0%)。然而,apvcs +材料对剩余接枝颗粒没有明显影响。结论:APVBCs用于窝内保存可减少垂直骨吸收,促进新骨形成。同时,APVBCs可以提高植骨材料的成骨效率。系统综述注册:https://www.crd.york.ac.uk/PROSPERO/view/CRD420250653020,标识符CRD420250653020。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The histological and radiological evaluation of autologous peripheral venous blood concentrates in socket preservation: a systematic review and meta-analysis.

The histological and radiological evaluation of autologous peripheral venous blood concentrates in socket preservation: a systematic review and meta-analysis.

The histological and radiological evaluation of autologous peripheral venous blood concentrates in socket preservation: a systematic review and meta-analysis.

The histological and radiological evaluation of autologous peripheral venous blood concentrates in socket preservation: a systematic review and meta-analysis.

Objectives: A detailed meta-analysis and systematic search was conducted to assess the histologic and radiographic efficacy of autologous peripheral venous blood concentrates (APVBCs) for the socket preservation.

Design: Electronic databases were searched until 31 January 2025. Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) in English were identified. Alveolar bone reconstruction was assessed through histologic and radiographic evaluation after tooth extraction. Data were analyzed using Revman5.3, and the risk of bias was evaluated with the Cochrane Collaboration tool.

Results: A total of 16 studies (12 RCTs and 4 CCTs) involving 619 sites was included in our meta-analysis. The results indicated that the APVBCs application significantly reduced the vertical bone resorption in the buccal ridge (standardized mean difference [SMD]: -0.30; 95% confidence interval [CI]: -0.54 to -0.06; p = 0.02, I 2 = 5%) and palatal/lingual ridge (SMD:-0.30, 95% CI: -0.54 to -0.06; p = 0.02, I 2 = 0%) by radiographic analysis. In addition, the vertical resorption of the buccal and palatal/lingual alveolar ridge was significantly reduced by using materials combined with APVBCs as the filling material for extraction sockets. The newly formed bone percentage showed a statistically significant increase in APVBC presence during socket preservation (SMD: 1.27, 95% CI: 0.65-1.89; p < 0.0001, I 2 = 71%) and APVBC + material groups (SMD: 0.85, 95% CI: 0.35-1.35; p = 0.0009, I 2 = 0%). However, APVBCs + materials did not show significant effects on the remaining graft particles.

Conclusions: APVBCs in socket preservation can reduce vertical bone resorption and enhance new bone formation. Meanwhile, APVBCs may improve osteogenic efficiency with bone graft material.

Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420250653020, identifier CRD420250653020.

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