胶原蛋白在人类皮肤的多样性：老化，伤口愈合和疾病。

IF 4.8 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Matrix Biology Pub Date : 2025-07-25 DOI:10.1016/j.matbio.2025.07.006

Mélanie Salamito , Valérie Haydont , Hervé Pageon , Florence Ruggiero , Sarah Girardeau-Hubert

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引用次数: 0

摘要

胶原蛋白是一种重要的皮肤蛋白质，占皮肤干重的75%。胶原蛋白超家族包括一组具有多种结构的蛋白质，这些蛋白质具有广泛的功能。皮肤中胶原蛋白的半衰期一般估计为10至15年；然而，不同类型的皮肤胶原蛋白的表达模式在人的一生中是不同的。内在和外在因素都会影响不同皮肤层内的胶原蛋白周转。在这篇综述中，我们讨论了目前对人类皮肤中不同类型胶原蛋白的了解，重点介绍了这些蛋白质在皮肤发育、体内平衡（包括衰老）、胶原相关病理、应激适应性以及伤口愈合相关过程和疾病中的动态作用。由于祖先起源和性别的皮肤多样性的特殊性也将被讨论。

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Collagen diversity in human skin: Aging, wound healing, and disorders

Collagen is an essential skin protein, accounting for 75 % of the skin’s dry weight. The collagen superfamily encompasses a diverse group of proteins with a variety of structures that fulfil a wide range of functions. The half-life of collagen in the skin is generally estimated at 10 to 15 years; however, the expression pattern of the different types of skin collagen varies throughout life. Both intrinsic and extrinsic factors influence collagen turn-over within the different skin layers. In this review, we discuss current knowledge of the different types of collagen present in human skin, focusing on insights gained from research exploring the dynamic roles of these proteins in skin development, homeostasis including aging, collagen-linked pathologies, adaptability in response to stress, and wound healing-related processes and disorders. Specificities of skin diversity due to ancestral origin and gender will also be discussed.

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来源期刊

Matrix Biology 生物-生化与分子生物学

CiteScore

11.40

自引率

4.30%

发文量

审稿时长

45 days

期刊介绍： Matrix Biology (established in 1980 as Collagen and Related Research) is a cutting-edge journal that is devoted to publishing the latest results in matrix biology research. We welcome articles that reside at the nexus of understanding the cellular and molecular pathophysiology of the extracellular matrix. Matrix Biology focusses on solving elusive questions, opening new avenues of thought and discovery, and challenging longstanding biological paradigms.