伤害感受器损伤驱动的结构和分子修饰。

IF 3.5 3区 生物学 Q1 BIOLOGY
Mario García-Domínguez
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引用次数: 0

摘要

外周组织损伤在伤害感受器(主要负责检测有害刺激的感觉神经元)内启动了多层面的结构和分子修饰级联。这些改变在疼痛状态的诱导和维持中起着至关重要的作用,包括急性和慢性疼痛。结构重塑包括轴突结构、树突形态和突触连通性的改变,它们共同影响伤害感受器的兴奋性和功能整合。同时,分子适应包括离子通道、受体表达和细胞内信号通路的调节,以及调节伤害性信号的转录重编程。这篇综述综合了目前关于损伤诱导的伤害感受器可塑性的细胞和分子基础的证据,确定了治疗干预以抵消适应不良致敏的预期目标。阐明这些过程对于疼痛治疗策略的进步和提高个体经历继发于组织损伤的神经性疼痛的临床结果至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Injury-Driven Structural and Molecular Modifications in Nociceptors.

Peripheral tissue injury initiates a multifaceted cascade of structural and molecular modifications within nociceptors, the primary sensory neurons tasked with detecting noxious stimuli. These alterations play a crucial role in the induction and maintenance of pain states, encompassing acute and chronic pain. Structural remodeling includes alterations in axonal architecture, dendritic morphology, and synaptic connectivity, collectively impacting nociceptor excitability and functional integration. Simultaneously, molecular adaptations comprise the regulation of ion channels, receptor expression, and intracellular signaling pathways, as well as transcriptional reprogramming that modulates nociceptive signaling. This review synthesizes current evidence regarding the cellular and molecular bases of injury-induced plasticity in nociceptors, identifying prospective targets for therapeutic intervention to counteract maladaptive sensitization. Elucidating these processes is critical for the advancement of pain treatment strategies and for enhancing clinical outcomes in individuals experiencing neuropathic pain secondary to tissue injury.

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来源期刊
Biology-Basel
Biology-Basel Biological Science-Biological Science
CiteScore
5.70
自引率
4.80%
发文量
1618
审稿时长
11 weeks
期刊介绍: Biology (ISSN 2079-7737) is an international, peer-reviewed, quick-refereeing open access journal of Biological Science published by MDPI online. It publishes reviews, research papers and communications in all areas of biology and at the interface of related disciplines. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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