Kenneth Micheal Madden, Boris Feldman, Graydon S Meneilly
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The Effects of Acarbose on the Postprandial Hypotensive Response in Older Adults.
Postprandial hypotension (PPH) is defined as a postprandial decline in systolic blood pressure (SBP) of 20 mm of Hg. Some have recommended the use of acarbose (an alpha-glucosidase inhibitor) as a potential therapy for PPH based exclusively on studies of older adults with diabetes. Using a randomized placebo-controlled design, 43 older adults (23 women, 20 men, mean age 77.1 ± 0.9 years) were recruited from geriatric medicine outpatient clinics in an academic centre. Although the average decrease in SBP during the meal test was significantly attenuated in the acarbose group (standardized β = 0.724 ± 0.286, p = 0.017), the acarbose group experienced significantly more PPH events (standardized β = 0.593 ± 0.279, p = 0.040). Although acarbose attenuated the mean decrease in SBP during the meal test, it did not reduce the actual number of PPH events recorded in a general population of older adults.ClinicalTrials.gov ID NCT01914133.
期刊介绍：
The Canadian Journal on Aging/La Revue canadienne du vieillissement (CJA/RCV) promotes excellence in research and disseminates the latest work of researchers in the social sciences, humanities, health and biological sciences who study the older population of Canada and other countries; informs policy debates relevant to aging through the publication of the highest quality research; seeks to improve the quality of life for Canada"s older population and for older populations in other parts of the world through the publication of research that focuses on the broad range of relevant issues from income security to family relationships to service delivery and best practices.
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