蓝色凝胶和氢氧化钙对具核梭菌和粪肠球菌生物膜的抑菌效果:离体研究。

IF 2.3 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Yahya Raja Alharbi, Swati Srivastava, Hanin Alsalhi, Khawlah Almohimeed, Mohammad Alduraibi, Ahmed Nabil
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引用次数: 0

摘要

根管治疗失败的原因可能是细菌持续存在,根管清洁和密封不充分,以及漏根管。有核梭菌和粪肠杆菌等细菌在根管系统内的弹性是导致根管治疗失败的一个重要原因。氢氧化钙(CaOH)是一种广泛应用于肛管内的药物,具有抗菌性能。然而,其在化学机械手术后持续实现培养阴性根管的能力仍然不一致。本研究旨在评价和比较CaOH和BlueM凝胶对牙本质圆盘上的具核梭菌和粪肠球菌生物膜的抑菌效果。从拔除的人牙齿中制备灭菌的牙本质盘。在这些圆盘上培养具核梭菌和粪芽孢杆菌,然后用过氧化氢或BlueM凝胶处理。通过量化菌落形成单位计数来评估抗菌效果。BlueM凝胶对具核梭菌和粪肠球菌生物膜的抑菌效果显著高于CaOH。两种制剂对生物膜均表现出明显的抑菌活性。与氢氧化钙相比,BlueM凝胶对牙髓病原菌(如具核梭菌和粪肠杆菌)的抗菌效果更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Antimicrobial efficacy of blueM gel and calcium hydroxide against F. nucleatum and E. faecalis biofilm: an ex-vivo study.

Antimicrobial efficacy of blueM gel and calcium hydroxide against F. nucleatum and E. faecalis biofilm: an ex-vivo study.

Antimicrobial efficacy of blueM gel and calcium hydroxide against F. nucleatum and E. faecalis biofilm: an ex-vivo study.

Endodontic treatment failure can result from persistent bacteria, inadequate cleaning and sealing of root canals, and missed canals. The resilience of bacteria such as F. nucleatum and E. faecalis within the root canal system is a significant cause of failed endodontic treatment. Calcium hydroxide (CaOH), a widely utilized intracanal medicament, has demonstrated antimicrobial properties. However, its ability to consistently achieve culture-negative root canals after chemo-mechanical procedures remains inconsistent. This study aimed to evaluate and compare the antimicrobial efficacy of CaOH and BlueM gel against F. nucleatum and E. faecalis biofilms using dentin discs. Sterilized dentin discs were prepared from extracted human teeth. F. nucleatum and E. faecalis were grown on these discs and then treated with either CaOH or BlueM gel. Antimicrobial efficacy was assessed by quantifying colony-forming unit counts. BlueM gel demonstrated significantly greater antimicrobial efficacy than CaOH against both F. nucleatum and E. faecalis biofilms. Both agents exhibited substantial antimicrobial activity against the biofilms. BlueM gel showed superior antimicrobial effectiveness against endodontic pathogens such as F. nucleatum and E. faecalis compared to CaOH.

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来源期刊
Saudi Dental Journal
Saudi Dental Journal DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.60
自引率
0.00%
发文量
86
审稿时长
22 weeks
期刊介绍: Saudi Dental Journal is an English language, peer-reviewed scholarly publication in the area of dentistry. Saudi Dental Journal publishes original research and reviews on, but not limited to: • dental disease • clinical trials • dental equipment • new and experimental techniques • epidemiology and oral health • restorative dentistry • periodontology • endodontology • prosthodontics • paediatric dentistry • orthodontics and dental education Saudi Dental Journal is the official publication of the Saudi Dental Society and is published by King Saud University in collaboration with Elsevier and is edited by an international group of eminent researchers.
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