Megan L Miller, Nathan D Seligson, Benjamin Q Duong, Josephine Elia, Shirin Hasan, Thomas Lacy, Kathryn V Blake, Kelsey J Cook
{"title":"儿科药物基因组学的机会:在多州儿科卫生系统中药物基因组学影响的精神药物处方趋势。","authors":"Megan L Miller, Nathan D Seligson, Benjamin Q Duong, Josephine Elia, Shirin Hasan, Thomas Lacy, Kathryn V Blake, Kelsey J Cook","doi":"10.5863/1551-6776-30.2.245","DOIUrl":null,"url":null,"abstract":"<p><p>The Clinical Pharmacogenetics Implementation Consortium (CPIC) has published guidelines providing pharmacogenomic (PGx) recommendations for more than 100 drugs; however, limited data exist describing prescribing patterns of these medications in pediatric populations. With increasing evidence describing the benefits of PGx testing to tailor drug therapy in psychiatric conditions, along with a worsening mental health crisis in pediatrics, it is vital to assess the prevalence of medication prescribing and potential impact of implementing PGx testing in this population. Here we describe prescribing patterns of psychiatric drugs classified as CPIC level A/B from January 1, 2010, through December 31, 2020, across Nemours Children's Health, a multistate pediatric health care system. We identified 21,442 unique patients who received at least 1 indicated medication during this period. The most frequently prescribed medications were amitriptyline and sertraline. Overall prescribing was highest in the departments of neurology, primary care, and psychiatry with selective serotonin reuptake inhibitors (SSRIs) being the most frequently prescribed medication class. These findings indicate ample opportunity for PGx implementation targeting these medications. Identification of high-prescribing departments and specific medications prescribed will help focus PGx implementation and education efforts.</p>","PeriodicalId":37484,"journal":{"name":"Journal of Pediatric Pharmacology and Therapeutics","volume":"30 2","pages":"245-249"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288568/pdf/","citationCount":"0","resultStr":"{\"title\":\"Opportunities for Pharmacogenomics in Pediatrics: Prescribing Trends of Psychiatric Medications With Pharmacogenomic Implications at a Multistate Pediatric Health System.\",\"authors\":\"Megan L Miller, Nathan D Seligson, Benjamin Q Duong, Josephine Elia, Shirin Hasan, Thomas Lacy, Kathryn V Blake, Kelsey J Cook\",\"doi\":\"10.5863/1551-6776-30.2.245\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The Clinical Pharmacogenetics Implementation Consortium (CPIC) has published guidelines providing pharmacogenomic (PGx) recommendations for more than 100 drugs; however, limited data exist describing prescribing patterns of these medications in pediatric populations. With increasing evidence describing the benefits of PGx testing to tailor drug therapy in psychiatric conditions, along with a worsening mental health crisis in pediatrics, it is vital to assess the prevalence of medication prescribing and potential impact of implementing PGx testing in this population. Here we describe prescribing patterns of psychiatric drugs classified as CPIC level A/B from January 1, 2010, through December 31, 2020, across Nemours Children's Health, a multistate pediatric health care system. We identified 21,442 unique patients who received at least 1 indicated medication during this period. The most frequently prescribed medications were amitriptyline and sertraline. Overall prescribing was highest in the departments of neurology, primary care, and psychiatry with selective serotonin reuptake inhibitors (SSRIs) being the most frequently prescribed medication class. These findings indicate ample opportunity for PGx implementation targeting these medications. Identification of high-prescribing departments and specific medications prescribed will help focus PGx implementation and education efforts.</p>\",\"PeriodicalId\":37484,\"journal\":{\"name\":\"Journal of Pediatric Pharmacology and Therapeutics\",\"volume\":\"30 2\",\"pages\":\"245-249\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288568/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pediatric Pharmacology and Therapeutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5863/1551-6776-30.2.245\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pediatric Pharmacology and Therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5863/1551-6776-30.2.245","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/14 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Opportunities for Pharmacogenomics in Pediatrics: Prescribing Trends of Psychiatric Medications With Pharmacogenomic Implications at a Multistate Pediatric Health System.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) has published guidelines providing pharmacogenomic (PGx) recommendations for more than 100 drugs; however, limited data exist describing prescribing patterns of these medications in pediatric populations. With increasing evidence describing the benefits of PGx testing to tailor drug therapy in psychiatric conditions, along with a worsening mental health crisis in pediatrics, it is vital to assess the prevalence of medication prescribing and potential impact of implementing PGx testing in this population. Here we describe prescribing patterns of psychiatric drugs classified as CPIC level A/B from January 1, 2010, through December 31, 2020, across Nemours Children's Health, a multistate pediatric health care system. We identified 21,442 unique patients who received at least 1 indicated medication during this period. The most frequently prescribed medications were amitriptyline and sertraline. Overall prescribing was highest in the departments of neurology, primary care, and psychiatry with selective serotonin reuptake inhibitors (SSRIs) being the most frequently prescribed medication class. These findings indicate ample opportunity for PGx implementation targeting these medications. Identification of high-prescribing departments and specific medications prescribed will help focus PGx implementation and education efforts.
期刊介绍:
The Journal of Pediatric Pharmacology and Therapeutics is the official journal of the Pediatric Pharmacy Advocacy Group. JPPT is a peer-reviewed multi disciplinary journal that is devoted to promoting the safe and effective use of medications in infants and children. To this end, the journal publishes practical information for all practitioners who provide care to pediatric patients. Each issue includes review articles, original clinical investigations, case reports, editorials, and other information relevant to pediatric medication therapy. The Journal focuses all work on issues related to the practice of pediatric pharmacology and therapeutics. The scope of content includes pharmacotherapy, extemporaneous compounding, dosing, methods of medication administration, medication error prevention, and legislative issues. The Journal will contain original research, review articles, short subjects, case reports, clinical investigations, editorials, and news from such organizations as the Pediatric Pharmacy Advocacy Group, the FDA, the American Academy of Pediatrics, the American Society of Health-System Pharmacists, and so on.