{"title":"优化改性膨润土霉菌毒素黏合剂在模拟胃肠条件下的吸附效率。","authors":"Javad Feizy, Atieh Rahimi, Damoon Ghofrani Tabari, Mohammad Reza Zarghami, Moslem Jahani, Elahe Moradi","doi":"10.1038/s41598-025-13249-z","DOIUrl":null,"url":null,"abstract":"<p><p>Mycotoxins-harmful compounds produced by various fungi, particularly in agricultural products-pose serious threats to food safety and to the health of both humans and livestock. These toxins can cause liver and kidney damage and may even be carcinogenic. Therefore, it is essential to mitigate their harmful effects through practical and cost-effective methods. In this study, we investigated the effectiveness of a mycotoxin binder composed of organic and inorganic materials with varying formulations for the removal of aflatoxins, ochratoxin, zearalenone, and deoxynivalenol under simulated gastric and intestinal conditions. Among the tested formulations, the mixture containing bentonite, humic acid, and beta-glucan-mannan in a 70:10:20 ratio showed the highest overall adsorption efficiency. This optimized formulation resulted in a statistically significant improvement in toxin removal (P < 0.05), achieving removal rates of 98.07% for aflatoxin B<sub>1</sub>, 93.80% for aflatoxin B<sub>2</sub>, 90.99% for aflatoxin G<sub>1</sub>, 93.56% for aflatoxin G<sub>2</sub>, 81.64% for ochratoxin, 73.45% for zearalenone, and 98.98% for deoxynivalenol. These findings offer a promising strategy for improving agricultural product safety and enhancing food supply chain integrity.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"27513"},"PeriodicalIF":3.9000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304100/pdf/","citationCount":"0","resultStr":"{\"title\":\"Optimization of modified bentonite mycotoxin binders for enhanced adsorption efficiency under simulated gastric and intestinal conditions.\",\"authors\":\"Javad Feizy, Atieh Rahimi, Damoon Ghofrani Tabari, Mohammad Reza Zarghami, Moslem Jahani, Elahe Moradi\",\"doi\":\"10.1038/s41598-025-13249-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Mycotoxins-harmful compounds produced by various fungi, particularly in agricultural products-pose serious threats to food safety and to the health of both humans and livestock. These toxins can cause liver and kidney damage and may even be carcinogenic. Therefore, it is essential to mitigate their harmful effects through practical and cost-effective methods. In this study, we investigated the effectiveness of a mycotoxin binder composed of organic and inorganic materials with varying formulations for the removal of aflatoxins, ochratoxin, zearalenone, and deoxynivalenol under simulated gastric and intestinal conditions. Among the tested formulations, the mixture containing bentonite, humic acid, and beta-glucan-mannan in a 70:10:20 ratio showed the highest overall adsorption efficiency. This optimized formulation resulted in a statistically significant improvement in toxin removal (P < 0.05), achieving removal rates of 98.07% for aflatoxin B<sub>1</sub>, 93.80% for aflatoxin B<sub>2</sub>, 90.99% for aflatoxin G<sub>1</sub>, 93.56% for aflatoxin G<sub>2</sub>, 81.64% for ochratoxin, 73.45% for zearalenone, and 98.98% for deoxynivalenol. These findings offer a promising strategy for improving agricultural product safety and enhancing food supply chain integrity.</p>\",\"PeriodicalId\":21811,\"journal\":{\"name\":\"Scientific Reports\",\"volume\":\"15 1\",\"pages\":\"27513\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-07-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304100/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scientific Reports\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1038/s41598-025-13249-z\",\"RegionNum\":2,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scientific Reports","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1038/s41598-025-13249-z","RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Optimization of modified bentonite mycotoxin binders for enhanced adsorption efficiency under simulated gastric and intestinal conditions.
Mycotoxins-harmful compounds produced by various fungi, particularly in agricultural products-pose serious threats to food safety and to the health of both humans and livestock. These toxins can cause liver and kidney damage and may even be carcinogenic. Therefore, it is essential to mitigate their harmful effects through practical and cost-effective methods. In this study, we investigated the effectiveness of a mycotoxin binder composed of organic and inorganic materials with varying formulations for the removal of aflatoxins, ochratoxin, zearalenone, and deoxynivalenol under simulated gastric and intestinal conditions. Among the tested formulations, the mixture containing bentonite, humic acid, and beta-glucan-mannan in a 70:10:20 ratio showed the highest overall adsorption efficiency. This optimized formulation resulted in a statistically significant improvement in toxin removal (P < 0.05), achieving removal rates of 98.07% for aflatoxin B1, 93.80% for aflatoxin B2, 90.99% for aflatoxin G1, 93.56% for aflatoxin G2, 81.64% for ochratoxin, 73.45% for zearalenone, and 98.98% for deoxynivalenol. These findings offer a promising strategy for improving agricultural product safety and enhancing food supply chain integrity.
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